Molecular structure of Guanosine 3′,5′-cyclic monophosphate, CAS Number: 7665-99-8
Guanosine 3′,5′-cyclic monophosphate (CAS 7665-99-8)
Alternate Names:
3′,5′-cGMP
Application:
Guanosine 3′,5′-cyclic monophosphate is an important second messenger
CAS Number:
7665-99-8
Purity:
≥98%
Molecular Weight:
345.21
Molecular Formula:
C10H12N5O7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanosine 3′,5′-cyclic monophosphate, known as cyclic guanosine monophosphate or cGMP, is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a secondary messenger in various biological processes, playing a role in signal transduction pathways within cells. cGMP is synthesized from GTP by the action of guanylate cyclase enzymes. There are two main types of guanylate cyclases: soluble guanylate cyclase (sGC), which is activated by nitric oxide (NO), and membrane-bound guanylate cyclase (mGC), which is activated by natriuretic peptides such as atrial natriuretic peptide (ANP). Once produced, cGMP exerts its effects by activating specific protein kinases, known as cGMP-dependent protein kinases, or by modulating the activity of cyclic nucleotide-gated ion channels and phosphodiesterases, which are enzymes responsible for the degradation of cGMP.
Guanosine 3′,5′-cyclic monophosphate (CAS 7665-99-8) References
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- Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells. | Matsuzawa, H. and Nirenberg, M. 1975. Proc Natl Acad Sci U S A. 72: 3472-6. PMID: 171662
- Generation of long RNA chains in water. | Costanzo, G., et al. 2009. J Biol Chem. 284: 33206-16. PMID: 19801553
- Human leukocyte migration inhibitory factor (LIF). IV. 3',5'-cGMP protects LIF against inactivation by the esterase inhibitor phenylmethylsulfonyl fluoride. | Bendtzen, K. 1977. Scand J Immunol. 6: 1357-61. PMID: 203999
- Human leucocyte migration inhibitory factor (LIF). V. Specific regulation of the lymphokine serine protease activity by 3',5'-cGMP and, possibly, 2',3'-cCMP. | Bendtzen, K. 1978. Scand J Immunol. 8: 53-61. PMID: 212822
- Gene cloning, expression, and characterization of a cyclic nucleotide phosphodiesterase from Arthrobacter sp. CGMCC 3584. | Zheng, Z., et al. 2013. Appl Biochem Biotechnol. 169: 2442-56. PMID: 23456275
- Untemplated nonenzymatic polymerization of 3',5'cGMP: a plausible route to 3',5'-linked oligonucleotides in primordia. | Šponer, JE., et al. 2015. J Phys Chem B. 119: 2979-89. PMID: 25625780
- Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. | Schneider, EH., et al. 2020. Naunyn Schmiedebergs Arch Pharmacol. 393: 1251-1267. PMID: 32313990
- Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP. | Wunnava, S., et al. 2021. Chemistry. 27: 17581-17585. PMID: 34726799
- Inhibition cyclic guanosine 3':5'-monophosphate of the soluble DNA polymerase activity, and of partially purified DNA polymerase A (DNA polymerase I) from the yeast Saccharomyces cerevisiae. | Eckstein, H. 1981. Z Naturforsch C Biosci. 36: 813-9. PMID: 6272506
- Signalling by cGMP-dependent protein kinases. | Vaandrager, AB. and de Jonge, HR. Mol Cell Biochem. 157: 23-30. PMID: 8739225
- Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. | Wang, X. and Robinson, PJ. 1997. J Neurochem. 68: 443-56. PMID: 9003029
- Distinct and specific functions of cGMP-dependent protein kinases. | Lohmann, SM., et al. 1997. Trends Biochem Sci. 22: 307-12. PMID: 9270304
- Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. | Browning, DD., et al. 1999. J Biol Chem. 274: 537-42. PMID: 9867877
- Direct high affinity modulation of connexin channel activity by cyclic nucleotides. | Bevans, CG. and Harris, AL. 1999. J Biol Chem. 274: 3720-5. PMID: 9920924
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1700042B14Rik.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanosine 3′,5′-cyclic monophosphate, 5 mg | sc-257569 | 5 mg | $75.00 | |||
Guanosine 3′,5′-cyclic monophosphate, 25 mg | sc-257569A | 25 mg | $254.00 |