Date published: 2025-12-7

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Guanosine 2′,3′-cyclic monophosphate sodium salt (CAS 15718-49-7)

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Alternate Names:
2′,3′-cGMP
CAS Number:
15718-49-7
Molecular Weight:
367.19
Molecular Formula:
C10H11N5O7P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Guanosine 2′,3′-cyclic monophosphate sodium salt (GMP) is a vital nucleotide present in all living cells, playing a significant role in cellular energy metabolism and the regulation of various cellular and physiological processes. Found in both the cytoplasm and nucleus of cells, GMP acts as a messenger molecule, contributing to the regulation of diverse biochemical pathways. Its use is highlighted in studies exploring signal transduction pathways, gene regulation, and cell metabolism.


Guanosine 2′,3′-cyclic monophosphate sodium salt (CAS 15718-49-7) References

  1. Inhibition by guanosine cyclic monophosphate (cGMP) analogues of uptake of [(3)H]3',5'-cGMP without stimulation of ATPase activity in human erythrocyte inside-out vesicles.  |  Boadu, E., et al. 2001. Biochem Pharmacol. 62: 425-9. PMID: 11448451
  2. An enzyme-linked immunosorbent assay for the rapid quantification of intracellular and extracellular guanosine 3',5'-cyclic monophosphate in cultured glial cells.  |  Wellard, J., et al. 2004. Neurochem Res. 29: 2177-87. PMID: 15662853
  3. Matrix interference-free method for the analysis of small molecules by using negative ion laser desorption/ionization on graphene flakes.  |  Lu, M., et al. 2011. Anal Chem. 83: 3161-9. PMID: 21428301
  4. Separation of nucleotides by hydrophilic interaction chromatography using the FRULIC-N column.  |  Padivitage, NL., et al. 2013. Anal Bioanal Chem. 405: 8837-48. PMID: 23995506
  5. Comparison of superficially porous and fully porous silica supports used for a cyclofructan 6 hydrophilic interaction liquid chromatographic stationary phase.  |  Dolzan, MD., et al. 2014. J Chromatogr A. 1365: 124-30. PMID: 25260342
  6. A facile and sensitive method for quantification of cyclic nucleotide monophosphates in mammalian organs: basal levels of eight cNMPs and identification of 2',3'-cIMP.  |  Jia, X., et al. 2014. Biomolecules. 4: 1070-92. PMID: 25513747
  7. RNase I regulates Escherichia coli 2',3'-cyclic nucleotide monophosphate levels and biofilm formation.  |  Fontaine, BM., et al. 2018. Biochem J. 475: 1491-1506. PMID: 29555843
  8. C. elegans AWA Olfactory Neurons Fire Calcium-Mediated All-or-None Action Potentials.  |  Liu, Q., et al. 2018. Cell. 175: 57-70.e17. PMID: 30220455
  9. Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease.  |  Attardi, DG., et al. 1985. EMBO J. 4: 3289-97. PMID: 3937725
  10. Interferon synthesis in human diploid cells pretreated with insulin.  |  Azuma, M., et al. 1978. Antimicrob Agents Chemother. 13: 566-9. PMID: 566528
  11. The identification of cyclic nucleotides from living systems using collision-induced dissociation of ions generated by fast atom bombardment mass spectrometry.  |  Kingston, EE., et al. 1984. Biomed Mass Spectrom. 11: 367-74. PMID: 6089928
  12. Guanosine triphosphate cyclohydrolase I assay in human and rat liver using high-performance liquid chromatography of neopterin phosphates and guanine nucleotides.  |  Blau, N. and Niederwieser, A. 1983. Anal Biochem. 128: 446-52. PMID: 6846819
  13. The ability of steroid hormones to control cAMP and cGMP production by human granulosa cells in culture.  |  Sirotkin, AV., et al. 1995. Cell Signal. 7: 61-5. PMID: 7756112

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Guanosine 2′,3′-cyclic monophosphate sodium salt, 50 µmol

sc-481308
50 µmol
$265.00