Guanidine-d5 deuteriochloride (CAS 108694-93-5)

Guanidine-d5 deuteriochloride is a deuterated variant of guanidine hydrochloride, characterized by the replacement of all hydrogen atoms with deuterium, a heavier isotope of hydrogen. This alteration enhances its utility in various scientific research applications, particularly in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, where the presence of deuterium allows for clearer and more distinct tracing of molecular interactions and dynamics. The use of Guanidine-d5 deuteriochloride is especially prevalent in studies of protein structure and folding; the compound acts as a denaturant, unfolding proteins in a way that can be meticulously analyzed due to the distinct vibrational modes of deuterium compared to hydrogen. This enables researchers to gain detailed insights into protein stability and the effects of denaturants on protein conformation. Additionally, in metabolic research, the deuterium labeling of this compound aids in the precise tracking of metabolic pathways, allowing scientists to observe the flow of materials through biochemical processes, thereby elucidating mechanisms that are otherwise obscured in complex biological systems. This makes Guanidine-d5 deuteriochloride a valuable tool in advancing the understanding of biochemical properties and interactions at a molecular level.