Molecular structure of Guanfacine hydrochloride, CAS Number: 29110-48-3
Guanfacine hydrochloride (CAS 29110-48-3)
Application:
Guanfacine hydrochloride is a selective α2A-AR adrenoceptor agonist
CAS Number:
29110-48-3
Purity:
>99%
Molecular Weight:
282.56
Molecular Formula:
C9H9Cl2N3O•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanfacine hydrochloride, a centrally acting anti-hypertensive agent, has been reported to be a specific α2A-AR adrenoceptor agonist. Activation of these α2A-AR adrenoreceptors has been shown to cause a decrease in blood pressure in vitro. Additional studies suggest that Guanfacine hydrochloride plays a role in solute/sodium osmoregulation and excretion.
Guanfacine hydrochloride (CAS 29110-48-3) References
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- Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat. | Milstein, JA., et al. 2007. Psychopharmacology (Berl). 190: 51-63. PMID: 17096085
- Stimulation of α(2A)-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex. | Ren, WW., et al. 2012. Mol Cell Neurosci. 49: 205-16. PMID: 22015717
- High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. | Huang, H., et al. 2012. Cell Rep. 2: 695-704. PMID: 22999940
- Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline. | Kauser, H., et al. 2013. Neuroscience. 254: 110-9. PMID: 24056194
- Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. | Chang, Q., et al. 2014. J Biol Chem. 289: 8337-52. PMID: 24519941
- α(2A)-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis. | Flavin, SA., et al. 2014. J Neurosci. 34: 9319-31. PMID: 25009265
- Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia. | Kauser, H., et al. 2016. Brain Res. 1636: 152-160. PMID: 26854138
- A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension. | Board, AW., et al. 1988. Clin Ther. 10: 761-75. PMID: 3064907
- Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. | Yu, JG., et al. 2019. Kaohsiung J Med Sci. 35: 202-208. PMID: 30896891
- Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity. | Yoshino, S., et al. 2020. Sci Rep. 10: 13671. PMID: 32792584
- Guanfacine hydrochloride: a centrally acting antihypertensive agent. | Cornish, LA. 1988. Clin Pharm. 7: 187-97. PMID: 3281788
- Heteromerization between α2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders. | Casadó-Anguera, V., et al. 2021. Pharmacol Res. 170: 105745. PMID: 34182128
- Alpha-subunit G-protein antisense oligodeoxynucleotide effects on supraspinal (i.c.v.) alpha2-adrenoceptor antinociception in mice. | Raffa, RB., et al. 1996. Life Sci. 58: PL 77-80. PMID: 8594300
- Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. | Intengan, HD. and Smyth, DD. 1997. J Pharmacol Exp Ther. 281: 48-53. PMID: 9103479
Activator of:
alpha2A-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanfacine hydrochloride, 10 mg | sc-203988 | 10 mg | $66.00 | |||
Guanfacine hydrochloride, 50 mg | sc-203988A | 50 mg | $230.00 |