Guanfacine hydrochloride CAS: 29110-48-3
MF: C9H9Cl2N3O•HCl
MW: 282.56
A selective α2A-AR adrenoceptor agonist.

Guanfacine hydrochloride (CAS 29110-48-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: Guanfacine hydrochloride is a selective α2A-AR adrenoceptor agonist
CAS Number: 29110-48-3
Purity: >99%
Molecular Weight: 282.56
Molecular Formula: C9H9Cl2N3O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Guanfacine hydrochloride, a centrally acting anti-hypertensive agent, has been reported to be a specific α2A-AR adrenoceptor agonist. Activation of these α2A-AR adrenoreceptors has been shown to cause a decrease in blood pressure in vitro. Additional studies suggest that Guanfacine hydrochloride plays a role in solute/sodium osmoregulation and excretion.


References

1. Cornish, L.A., 1988. Clin Pharm. 7: 187-197. PMID: 3281788
2. Board, A.W., et al. 1988. Clin Ther. 10: 761-775. PMID: 3064907
3. Uhlén, S. and Wikberg, J.E. 1991. Eur. J. Pharmacol. 202: 235-243. PMID: 1666366
4. Intengan, H.D., et al. 1997. J. Pharmacol. Exp. Ther. 281: 48-53. PMID: 9103479

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
213-216° C
Boiling Point :
424.9° C at 760 mmHg (Predicted) (tautomer)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 2.51 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY1481000
PubChem CID :
71401
MDL Number :
MFCD00798230
SMILES :
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 99ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.