Molecular structure of Guanethidine sulfate, CAS Number: 645-43-2
Guanethidine sulfate (CAS 645-43-2)
See product citations (10)
Alternate Names:
Guanethidine sulfate is also known as N-[2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine sulfate.
Application:
Guanethidine sulfate is an antihypertensive and antiglaucoma compound, competitive with norepinephrine in adrenergic neuron transport.
CAS Number:
645-43-2
Purity:
≥99%
Molecular Weight:
296.39
Molecular Formula:
C10H22N4•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanethidine sulfate is a compound that is of particular interest in cardiovascular and neurological research. It is known to inhibit the release of neurotransmitters from sympathetic nerve endings. This mechanism is exploited in research focused on understanding sympathetic nervous system function and its impact on blood pressure regulation. Studies utilizing guanethidine sulfate often explore its effects on neurotransmitter storage and release, providing insights into the molecular details of synaptic transmission. Additionally, the compound is used in experiments designed to induce chemical sympathectomy, allowing researchers to study the outcomes of reduced sympathetic activity in various physiological systems.
Guanethidine sulfate (CAS 645-43-2) References
- [Guanethidine sulfate (ismeline) and adrenaline in the treatment of postoperative secondary and residual glaucoma]. | Ourgaud, AG. and Chagnon, A. 1976. Bull Soc Ophtalmol Fr. 76: 517-21. PMID: 1052150
- Severe essential hypertension treated by guanethidine sulfate with hydrochlorthiazide. | GREENSTEIN, S. 1961. J Albert Einstein Med Cent (Phila). 9: 198-205. PMID: 13708357
- The antihypertensive effect of guanethidine sulfate. | ZIEGLER, RW., et al. 1961. J La State Med Soc. 113: 221-3. PMID: 13788429
- The initial pressor actions of bretylium tosylate and guanethidine sulfate and their relation to release of catecholamines. | GILLIS, CN. and NASH, CW. 1961. J Pharmacol Exp Ther. 134: 1-7. PMID: 13898659
- Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice. | Marenzana, M., et al. 2007. Bone. 41: 206-15. PMID: 17543595
- Effects of neonatal sympathectomy with 6-hydroxydopamine or guanethidine on survival of neurons in the intermediolateral cell column of rat spinal cord. | Krukoff, TL., et al. 1990. J Auton Nerv Syst. 31: 119-26. PMID: 2127052
- Guanethidine-induced adrenergic sympathectomy augments endoneurial perfusion and lowers endoneurial microvascular resistance. | Zochodne, DW., et al. 1990. Brain Res. 519: 112-7. PMID: 2397398
- Effect of sympathectomy on ontogeny of small intestinal disaccharidases in the rat. | Grunwald, Z., et al. 1987. J Pediatr Gastroenterol Nutr. 6: 784-8. PMID: 3694373
- Sociosexual behaviors of female rats during and after chronic treatment with the sympatholytic agent guanethidine. | Emery, DE. 1985. Pharmacol Biochem Behav. 23: 267-73. PMID: 4059312
- Guanethidine sulfate in the prevention of autonomic hyperreflexia. | Brown, BT., et al. 1979. J Urol. 122: 55-7. PMID: 458989
- [Determination of (2-(octahydro-1'-azocinyl)ethyl) guanidine sulfate (guanethidine sulfate) in non-aqueous mdium. Thin layer chromatography of guanethidine sulfate]. | Tománková, H. 1970. Cesk Farm. 19: 96-8. PMID: 5423295
- Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. | Mitchell, JR., et al. 1967. JAMA. 202: 973-6. PMID: 5630743
- Outflow facility after guanethidine sulfate administration. | Bonomi, L. and DiComite, P. 1967. Arch Ophthalmol. 78: 337-40. PMID: 6040011
- Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats. | Herskovits, MS. and Singh, IJ. 1982. J Exp Zool. 223: 97-101. PMID: 7130940
- Guanadrel. A new antihypertensive drug. | Dunn, MI. and Dunlap, JL. 1981. JAMA. 245: 1639-42. PMID: 7206175
Inhibitor of:
Chr-A, D930020B18Rik, Olfr446, Olfr855, Olfr857, Olfr866, and TRH-DE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanethidine sulfate, 1 g | sc-211570 | 1 g | $238.00 |