Molecular structure of GTP 14564, CAS Number: 34823-86-4
GTP 14564 (CAS 34823-86-4)
See product citations (3)
Application:
GTP 14564 is a specific inhibitor of class III receptor tyrosine kinases
CAS Number:
34823-86-4
Purity:
>98%
Molecular Weight:
234.26
Molecular Formula:
C15H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GTP 14564 is a cell-permeable tricyclic benzofurano-indazolo compound which functions as a specific inhibitor of class III receptor tyrosine kinases. Studies show that GTP 14564 can be used to track the signaling pathways activated by FLT3 and ITD-FLT3 in Ba/F3 cells. Furthermore, GTP 14564 can suppress the FLT3 internal tandem duplication (ITD) cells to the same extent as FLT3 siRNA. Studies show that if combined with 17-AAG, GTP 14564 can reduce the levels of p-FLT3 and p-STAT5 and can amplify apoptosis and G0/G1 arrest in FLT3-ITD cells.
GTP 14564 (CAS 34823-86-4) References
- Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). | Murata, K., et al. 2003. J Biol Chem. 278: 32892-8. PMID: 12815052
- Small molecule FLT3 tyrosine kinase inhibitors. | Levis, M. and Small, D. 2004. Curr Pharm Des. 10: 1183-93. PMID: 15078134
- Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. | Yao, Q., et al. 2005. Leukemia. 19: 1605-12. PMID: 16034464
- Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. | Schenone, S., et al. 2008. Curr Med Chem. 15: 3113-32. PMID: 19075657
- Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation. | Perugini, M., et al. 2009. Leukemia. 23: 729-38. PMID: 19151789
- Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. | Jacobi, A., et al. 2010. Exp Hematol. 38: 180-90. PMID: 20035824
- mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells. | Chen, W., et al. 2010. Mol Cancer. 9: 292. PMID: 21067588
- Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. | Herraiz, C., et al. 2011. Mol Endocrinol. 25: 138-56. PMID: 21084381
- A chemical screen identifies small molecules that regulate hepcidin expression. | Gaun, V., et al. 2014. Blood Cells Mol Dis. 53: 231-40. PMID: 24998898
- Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. | Zhang, H., et al. 2014. Curr Biol. 24: 2501-8. PMID: 25438940
Inhibitor of:
c-Fms-CSF-1R, c-Kit, Enzyme, Flt-3/Flk-2, and PDGFR-beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GTP 14564, 10 mg | sc-203062 | 10 mg | $129.00 |