GSK461364 (CAS 929095-18-1)
Alternate Names:
(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide
Application:
GSK461364 is a Plk inhibitor with anti-proliferative effects on certain tumor cells
CAS Number:
929095-18-1
Molecular Weight:
543.6
Molecular Formula:
C27H28F3N5O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GSK461364 is a thiophene amide that inhibits purified Plk1 with a Ki of 2 nM and has >100-fold selectivity for Plk1 compared with Plk2 and Plk3. . GSK461364 shows anti-proliferative activity against multiple (>120) tumor cell lines and potently inhibits the proliferation of more than 83% and 91% of these cell lines, with IC50 values lower than 50 and 100 nM, respectively.
Inhibitor of:
BC061194, Cdc5, D4Wsu53e, EG633057, Enzyme, FBXW26, H-plk, HAUS5_Haus5, Integrin, Plk, Plk5, Snk, STK31, and Tom22.Activator of:
BUB3, BUBR1, H-plk, and Kizuna_Plk1s1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK461364, 10 mg | sc-364504 | 10 mg | $500.00 | |||
GSK461364, 50 mg | sc-364504A | 50 mg | $1540.00 |