Molecular structure of GSK257821A, CAS Number: 1285515-21-0
GSK257821A (CAS 1285515-21-0)
Alternate Names:
GSK 257821A; GSK-257821A
Application:
GSK257821A is an inhibitor of LRRK2
CAS Number:
1285515-21-0
Purity:
≥98%
Molecular Weight:
399.42
Molecular Formula:
C24H18FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GSK257821A is a potent inhibitor of LRRK2 (leucine-rich repeat kinase-2). GSK257821A inhibits both wild-type and G2019S mutant LRRK2 with IC50s of 10.9 and 8.9, respectively. The compound has been shown to have high blood-brain barrier permeability in mice.
GSK257821A (CAS 1285515-21-0) References
A.D. Reith et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg. Med. Chem. Lett. 2012, 22, 5625-5629.M.E. Kavanagh et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg. Med. Chem. Lett. 2013, 23, 3690-3696.
Inhibitor of:
LRRK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK257821A, 5 mg | sc-396100 | 5 mg | $81.00 |