Molecular structure of GSK1838705A, CAS Number: 1116235-97-2
GSK1838705A (CAS 1116235-97-2)
Application:
GSK1838705A is an ATP-competitive inhibitor of IGF-IR, IR, and ALK in various cell lines
CAS Number:
1116235-97-2
Molecular Weight:
532.57
Molecular Formula:
C27H29FN8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK1838705A is an ATP-competitive inhibitor of IGF-IR and IR, with Ki values of 0.7 nM and 1.1 nM, respectively, and cellular IC 50 values of 85 nM and 79 nM, respectively. GSK1838705A shows anti-proliferative effects in L-82, SUP-M2, SK-ES and MCF-7 and NPM-ALK cells with EC50 of 24 nM, 28 nM, 141 nM, 203 nM, and 24-88 nM respectively. GSK1838705A shows an accumulation of MCF-7 and NCl-H929 cells predominantly in G1 (2N) phase of the cell cycle. GSK1838705A potently inhibits NPM-ALK phosphorylation in Karpas-299 and SR-786 cells, while has modest effect on STAT3 phosphorylation.
Inhibitor of:
BZW1, CRN, Cypt3, ephrin-B2, IGF-IB, IGF-II, IGF-IR, IGF-IRα, IGFBP6, IGFBPL1, and insulin R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK1838705A, 5 mg | sc-364502 | 5 mg | $240.00 | |||
GSK1838705A, 50 mg | sc-364502A | 50 mg | $992.00 |