Molecular structure of GSK-J4, CAS Number: 1373423-53-0
GSK-J4 (CAS 1373423-53-0)
Alternate Names:
ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate
CAS Number:
1373423-53-0
Molecular Weight:
417.513
Molecular Formula:
C24H27N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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GSK-J4 (CAS 1373423-53-0) References
- GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies. | Mandal, C., et al. 2017. Mol Cells. 40: 737-751. PMID: 29047260
- Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer. | Lin, B., et al. 2020. Front Pharmacol. 11: 632. PMID: 32477122
- GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells. | Chu, X., et al. 2020. Cancer Cell Int. 20: 209. PMID: 32514253
- Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts. | Sanchez, A., et al. 2022. Cancer Genomics Proteomics. 19: 339-349. PMID: 35430567
- GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis. | Xu, K., et al. 2022. Front Cardiovasc Med. 9: 907747. PMID: 35722096
- The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation. | Hung, PH., et al. 2022. Int J Mol Sci. 23: PMID: 36012674
- CCL17 Blockade by CCL17mAb/GSK-J4 Ameliorates Hyperalgesia in a Rat Model of Postoperative Pain. | Zhang, Z., et al. 2023. Biol Pharm Bull. 46: 533-541. PMID: 36792181
- GSK-J4: An H3K27 histone demethylase inhibitor, as a potential anti-cancer agent. | Dalpatraj, N., et al. 2023. Int J Cancer. 153: 1130-1138. PMID: 37165737
- Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. | Zheng, C., et al. 2023. Adv Sci (Weinh). 10: e2206798. PMID: 37330650
- GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling. | Sadeghi, L. and Wright, APH. 2023. Cells. 12: PMID: 37566089
Inhibitor of:
2400001E08Rik, ALKBH3, ALKBH4, ALKBH5, ALKBH6, ANKRD24, ANKS4B, BC066135, BC068157, BC094916, BC100530, BC106175, BCORL1, CHD (chromodomain helicase), CHD7, COL20A1, D5Ertd577e, DBC1, E130012A19Rik, E430029J22Rik, EG408191, EG432502, EG434797, FBXW18, HEB, Histone cluster 1 H2AA, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3F, JMJD1A, JMJD1B, JMJD2B, JMJD2C, JMJD2D, KDM (lysine demethylase), KRTAP13-3, KTELC1, Mel-18, Mi2-β, MSL-1, NO66, Olfr64, OTTMUSG00000016785, OTTMUSG00000016788, PCDHGA10, PLU-1, PRDM16, SETD6, Six1, TADA2L, Tomm20l, TRIM27, UNQ6126, UTY, XAGE-1C, and ZSCAN4B.Activator of:
AF-10, ARID2, CARM1, D5Ertd577e, DXBay18, E130311K13Rik, E230019M04Rik, EG278167, ELL, FGF-19, SLUG, and SUV420H1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-J4, 100 mg | sc-507551 | 100 mg | $1275.00 |