Molecular structure of GSK 789472 hydrochloride, CAS Number: 1257326-24-1
GSK 789472 hydrochloride (CAS 1257326-24-1)
Application:
GSK 789472 hydrochloride is GSK 789472 hydrochloride is a specific D3DR antagonist and D2DR partial agonist
CAS Number:
1257326-24-1
Purity:
≥95%
Molecular Weight:
295.81
Molecular Formula:
C15H21N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
GSK 789472 hydrochloride is a compound. The compound described is a selective antagonist for the dopamine D3 receptor and a partial agonist for the dopamine D2 receptor. It exhibits potent activity with pEC50 values below 5.5 for D3 receptor antagonism and 8.3 for D2 receptor partial agonism. Notably, it demonstrates selectivity against the D4 receptor in both agonist and antagonist assays.
GSK 789472 hydrochloride (CAS 1257326-24-1) References
- The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure. | Holmes, IP., et al. 2010. Bioorg Med Chem Lett. 20: 2013-6. PMID: 20153647
- Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. | Sharopov, S., et al. 2012. J Neurosci Res. 90: 2020-33. PMID: 22714119
Inhibitor of:
D3DR, and D4DR.Substrate of:
D2DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 789472 hydrochloride, 10 mg | sc-358242 | 10 mg | $155.00 | |||
GSK 789472 hydrochloride, 50 mg | sc-358242A | 50 mg | $660.00 |