Molecular structure of GSK 4716, CAS Number: 101574-65-6
GSK 4716 (CAS 101574-65-6)
Alternate Names:
GW4716
Application:
GSK 4716 is a selective agonist with estrogen-related receptors ERRβ and ERRγ
CAS Number:
101574-65-6
Molecular Weight:
282.34
Molecular Formula:
C17H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Selective agonist with estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and classical estrogen receptors.
GSK 4716 (CAS 101574-65-6) References
- Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach. | Kim, Y., et al. 2009. J Comb Chem. 11: 928-37. PMID: 19746993
- BPA Directly Decreases GnRH Neuronal Activity via Noncanonical Pathway. | Klenke, U., et al. 2016. Endocrinology. 157: 1980-90. PMID: 26934298
- Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis. | Son, YO. and Chun, JS. 2018. BMB Rep. 51: 165-166. PMID: 29366446
- Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists. | Lin, H., et al. 2018. Bioorg Med Chem Lett. 28: 1313-1319. PMID: 29548571
- A Selective ERRα/γ Inverse Agonist, SLU-PP-1072, Inhibits the Warburg Effect and Induces Apoptosis in Prostate Cancer Cells. | Schoepke, E., et al. 2020. ACS Chem Biol. 15: 2338-2345. PMID: 32897058
- Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis. | Tang, J., et al. 2021. Mol Med. 27: 5. PMID: 33446092
- Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development. | George, JJ., et al. 2021. Cell Mol Gastroenterol Hepatol. 12: 873-889. PMID: 34058415
Inhibitor of:
GPR30, mPRα, and NR3B.Activator of:
apoD, EAR2, ERR beta, ERR gamma, ERRα, resistin, and TR β.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 4716, 10 mg | sc-203986 | 10 mg | $71.00 | |||
GSK 4716, 50 mg | sc-203986A | 50 mg | $285.00 |