Date published: 2026-5-24

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GSK-3β substrate Substrate

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Alternate Names:
H-GPHRSTPESRAAV-OH
Application:
GSK-3β substrate is sequence corresponds to the hydrophilic loop domain of presenilin 1 that is selectively recognized by GSK-3b
Purity:
>97% pure by HPLC
Molecular Weight:
1364.5
Molecular Formula:
C56H93N21O19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The GSK-3β substrate is a critical tool in molecular research, designed to interact specifically with glycogen synthase kinase-3 beta (GSK-3β) for phosphorylation within cellular signaling pathways. GSK-3β is a multifunctional serine/threonine kinase involved in various cellular processes, including glycogen metabolism, cell proliferation, and neuronal function. The substrate facilitates the investigation of GSK-3β-mediated phosphorylation events and downstream signaling cascades, allowing researchers to explain the enzyme′s role in physiological and pathological conditions. Widely utilized in biochemical and cell biology studies, the GSK-3β substrate has provided valuable insights into GSK-3β signaling and its implications in cellular processes. Moreover, its utilization has led to the identification of novel GSK-3β substrates and regulatory mechanisms, contributing to a better understanding of the enzyme′s function and its involvement in cellular signaling networks. Continued exploration using the GSK-3β substrate holds promise for uncovering further insights into the functional significance of GSK-3β in cellular physiology and pathology, ultimately advancing our knowledge of its role in health and disease.


GSK-3β substrate Substrate References

  1. Protein kinase C epsilon mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells.  |  Flescher, E. and Rotem, R. 2002. Cell Signal. 14: 37-43. PMID: 11747987
  2. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.  |  Ha, NC., et al. 2004. Mol Cell. 15: 511-21. PMID: 15327768
  3. Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain.  |  Ryan, KA. and Pimplikar, SW. 2005. J Cell Biol. 171: 327-35. PMID: 16230462
  4. The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.  |  Kanno, T., et al. 2006. J Lipid Res. 47: 1146-56. PMID: 16520488
  5. Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate.  |  Twomey, C. and McCarthy, JV. 2006. FEBS Lett. 580: 4015-20. PMID: 16814287
  6. Inhibition of glycogen synthase kinase-3 reduces L-DOPA-induced neurotoxicity.  |  Koh, SH., et al. 2008. Toxicology. 247: 112-8. PMID: 18387727
  7. Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway.  |  Tao, J., et al. 2009. Cell Signal. 21: 1436-43. PMID: 19439178
  8. Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons.  |  Zhang, Y., et al. 2010. Cell Signal. 22: 1660-8. PMID: 20599609
  9. Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor.  |  Licht-Murava, A., et al. 2011. J Mol Biol. 408: 366-78. PMID: 21354422
  10. Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells.  |  Shi, J., et al. 2012. FEBS Lett. 586: 2443-50. PMID: 22687243

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GSK-3β substrate, 1 mg

sc-3114
1 mg
$172.00