Molecular structure of GSK-3β Inhibitor XII, TWS119, CAS Number: 601514-19-6
GSK-3β Inhibitor XII, TWS119 (CAS 601514-19-6)
See product citations (10)
Alternate Names:
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol; TWS-119
Application:
GSK-3β Inhibitor XII, TWS119 is a cell-permeable agent shown to act as a potent inhibitor of GSK-3β
CAS Number:
601514-19-6
Purity:
≥90%
Molecular Weight:
318.33
Molecular Formula:
C18H14N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
GSK-3beta Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that may act to act as a potent inhibitor of GSK-3beta (IC50 = 30 nM). In addition, GSK-3beta Inhibitor XII, TWS119 is thought to bind GSK-3beta with high-affinity (Kd = 126 nM) and increases the level of beta-catenin, a downstream substrate of GSK-3beta in the Wnt signaling pathway. This activity may act to selectively induce neuronal differentiation in both embryonic stem cells (D3 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19 30-40% at 1muM). As result of GSK-3beta Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.
GSK-3β Inhibitor XII, TWS119 (CAS 601514-19-6) References
- Synthetic small molecules that control stem cell fate. | Ding, S., et al. 2003. Proc Natl Acad Sci U S A. 100: 7632-7. PMID: 12794184
- Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. | Kordes, C., et al. 2008. Biochem Biophys Res Commun. 367: 116-23. PMID: 18158920
- GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro. | Ono, M., et al. 2011. Platelets. 22: 196-203. PMID: 21231855
- Lithium Attenuates TGF-β(1)-Induced Fibroblasts to Myofibroblasts Transition in Bronchial Fibroblasts Derived from Asthmatic Patients. | Michalik, M., et al. 2012. J Allergy (Cairo). 2012: 206109. PMID: 22988467
- Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells. | Zhou, YX., et al. 2016. J Cell Physiol. 231: 393-402. PMID: 26129946
- GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. | Wang, W., et al. 2016. Mol Neurobiol. 53: 7028-7036. PMID: 26671619
- GSK-3β as a target for protection against transient cerebral ischemia. | Wang, W., et al. 2017. Int J Med Sci. 14: 333-339. PMID: 28553165
- Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. | Chen, YQ., et al. 2018. Exp Cell Res. 362: 63-71. PMID: 29104081
- Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer. | Tang, YY., et al. 2018. J Immunother. 41: 319-328. PMID: 29877972
- The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility. | Jin, F., et al. 2019. Cancer Biol Med. 16: 38-54. PMID: 31119045
- GSK-3β inhibitor TWS119 alleviates hypoxic-ischemic brain damage via a crosstalk with Wnt and Notch signaling pathways in neonatal rats. | Gao, L., et al. 2021. Brain Res. 1768: 147588. PMID: 34310937
- Premise and peril of Wnt signaling activation through GSK-3β inhibition. | Law, SM. and Zheng, JJ. 2022. iScience. 25: 104159. PMID: 35434563
- GSK-3β/β-catenin pathway plays crucial roles in the regulation of NK cell cytotoxicity against myeloma cells. | Ren, J., et al. 2023. FASEB J. 37: e22821. PMID: 36794671
Inhibitor of:
GSK-3 beta, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3β Inhibitor XII, TWS119, 1 mg | sc-221694 | 1 mg | $62.00 | |||
GSK-3β Inhibitor XII, TWS119, 5 mg | sc-221694A | 5 mg | $161.00 |