GSK-3beta Inhibitor XII, TWS119 CAS: 601514-19-6
MF: C18H14N4O2
MW: 318.33
A cell-permeable agent shown to act as a potent inhibitor of GSK-3β.

GSK-3β Inhibitor XII, TWS119 (CAS 601514-19-6)

GSK-3β Inhibitor XII, TWS119 | CAS 601514-19-6 is rated 5.0 out of 5 by 1.
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Synonym: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol; TWS-119
Application: A cell-permeable agent shown to act as a potent inhibitor of GSK-3β
CAS Number: 601514-19-6
Purity: ≥90%
Molecular Weight: 318.33
Molecular Formula: C18H14N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.


References

1. Ding, S., et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 7632-7637. PMID: 12794184
2. Kordes, C., et al. 2008. Biochem. Biophys. Res. Commun. 367: 116-123. PMID: 18158920

Physical State :
Solid
Solubility :
Soluble in DMSO or Methanol
Storage :
Store at 4° C
Boiling Point :
646.0±55.0° C at 760 mmHg (Predicted)
Density :
1.4±0.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9549289
SMILES :
C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O

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GSK-3beta Inhibitor XII, TWS119  Product Citations

See how others have used GSK-3beta Inhibitor XII, TWS119. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 30417576  Shi, X. et al. 2018. J. Cell. Mol. Med.

PMID: # 30224477  Gennaro, VJ. et al. 2018. Proc. Natl. Acad. Sci. U.S.A. 115: E9298-E9307.

PMID: # 27187477  Bordonaro, M. et al. 2016. Cancers (Basel). 8:

PMID: # 26716413  Cui, HY. et al. 2016. Oncotarget. 7: 5613-29.

PMID: # 26163895  Jiang, H. et al. 2015. Experimental cell research.

Citations 1 to 5 of 5 total

Per quale motivo questi inibitori vengono identificati con i numeri romani?

Asked by: Eleonora90
Grazie per la tua domanda. I numeri romani sono un modo comune per identificare diversi inibitori GSK-3. Puoi trovare tutti gli inibitori GSK-3 che offriamo seguendo questo link: https://www.scbt.com/scbt/de/search?Ntt=GSK-3+Inhibitor. Possono anche essere trovati dai rispettivi numeri CAS. Se hai ulteriori domande, ti preghiamo di metterti in contatto con il nostro servizio tecnico. 'Why are these inhibitors identified with roman numerals?' Thank you for your question. Roman numerals are a common way of identifying different GSK-3 inhibitors. You can find all GSK-3 inhibitors we offer by following this link: https://www.scbt.com/scbt/de/search?Ntt=GSK-3+Inhibitor. They can also be found by their respective CAS numbers. If you have further questions, please get in touch with our technical service.
Answered by: Technical Support Europe
Date published: 2019-05-06
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Rated 5 out of 5 by from Xiao Xiao, Z. et al. (PubMed 23911398) used TWS119 (GSK-3 Inhibitor XII) to activate Wnt signaling. -SCBT Publication Review
Date published: 2015-05-02
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