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GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.
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See how others have used GSK-3beta Inhibitor XII, TWS119. Click on the entry to view the PubMed entry .
PMID: # 30417576 Shi, X. et al. 2018. J. Cell. Mol. Med.
PMID: # 30224477 Gennaro, VJ. et al. 2018. Proc. Natl. Acad. Sci. U.S.A. 115: E9298-E9307.
PMID: # 27187477 Bordonaro, M. et al. 2016. Cancers (Basel). 8:
PMID: # 26716413 Cui, HY. et al. 2016. Oncotarget. 7: 5613-29.
PMID: # 26163895 Jiang, H. et al. 2015. Experimental cell research.
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