Molecular structure of GSK-3β Inhibitor VII, CAS Number: 99-73-0
GSK-3β Inhibitor VII (CAS 99-73-0)
Alternate Names:
2,4′-Dibromoacetophenone
Application:
GSK-3β Inhibitor VII is a cell-permeable, and non-ATP competitive inhibitor of GSK-3β
CAS Number:
99-73-0
Purity:
≥99%
Molecular Weight:
277.94
Molecular Formula:
C8H6Br2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.
GSK-3β Inhibitor VII (CAS 99-73-0) References
- Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching. | Conde, S., et al. 2003. J Med Chem. 46: 4631-3. PMID: 14561081
- Pharmacological inhibitors of glycogen synthase kinase 3. | Meijer, L., et al. 2004. Trends Pharmacol Sci. 25: 471-80. PMID: 15559249
- Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells. | Li, Z., et al. 2007. Mol Cancer Ther. 6: 3113-21. PMID: 18089706
- Adenylate cyclase regulates elongation of mammalian primary cilia. | Ou, Y., et al. 2009. Exp Cell Res. 315: 2802-17. PMID: 19576885
- Role of 70-kDa ribosomal protein S6 kinase, nitric oxide synthase, glycogen synthase kinase-3 beta, and mitochondrial permeability transition pore in desflurane-induced postconditioning in isolated human right atria. | Lemoine, S., et al. 2010. Anesthesiology. 112: 1355-63. PMID: 20460998
- Prophylactic lithium alleviates postoperative cognition impairment by phosphorylating hippocampal glycogen synthase kinase-3β (Ser9) in aged rats. | Zhao, L., et al. 2011. Exp Gerontol. 46: 1031-6. PMID: 21945291
- Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death. | Enomoto, A., et al. 2012. Free Radic Biol Med. 52: 507-15. PMID: 22142472
- GSK-3β signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition. | Gavilán, E., et al. 2013. Cell Death Dis. 4: e572. PMID: 23559006
- Serine-Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint. | Fukasawa, T., et al. 2015. Cell Signal. 27: 1569-75. PMID: 25936524
- Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism. | Gavilán, E., et al. 2015. Sci Rep. 5: 10027. PMID: 25941117
Inhibitor of:
Enzyme, group II sPLA2, and GSK-3 beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3β Inhibitor VII, 5 mg | sc-202635 | 5 mg | $129.00 |