Date published: 2025-10-15

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GSK-3 Inhibitor IX, Control, MeBIO (CAS 710323-61-8)

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Alternate Names:
1-Methyl-BIO
Application:
GSK-3 Inhibitor IX, Control, MeBIO is a cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX
CAS Number:
710323-61-8
Purity:
≥97%
Molecular Weight:
370.2
Molecular Formula:
C17H12BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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GSK-3 Inhibitor IX, Control, MeBIO is a cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX (sc-202634). The compound has been shown to act as a kinase negative control (IC50 > 92 μM for Cdk1/B, > 100 μM for Cdk5/p25, and GSK-3 α/β ). MeBIO has been documented to act as a potent ligand for aryl hydrocarbon receptors at an EC50 = 20 nM for yeast and and EC50 =93 nM for hepatoma reporter systems. The compound has also demonstrated antiproliferative properties.


GSK-3 Inhibitor IX, Control, MeBIO (CAS 710323-61-8) References

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  3. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.  |  Knockaert, M., et al. 2004. Oncogene. 23: 4400-12. PMID: 15077192
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  6. Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells.  |  Umeda, K., et al. 2012. Sci Rep. 2: 455. PMID: 22701159
  7. Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.  |  Das, S., et al. 2013. J Biol Chem. 288: 11824-33. PMID: 23508962
  8. Antimicrobial secondary metabolites from marine gastropod egg capsules and egg masses.  |  Kaviarasan, T., et al. 2012. Asian Pac J Trop Biomed. 2: 916-22. PMID: 23569871
  9. CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin.  |  Flentke, GR., et al. 2014. J Neurochem. 128: 523-35. PMID: 24117889

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GSK-3 Inhibitor IX, Control, MeBIO, 1 mg

sc-221688
1 mg
$135.00