Molecular structure of GSK 1059615, CAS Number: 958852-01-2
GSK 1059615 (CAS 958852-01-2)
Application:
GSK 1059615 is a potent inhibitor of PI 3-kinase and FRAP (mTOR)
CAS Number:
958852-01-2
Molecular Weight:
333.36
Molecular Formula:
C18H11N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GSK 1059615, a pyridinylquinoline derivative, is a novel, ATP-competitive, and reversible class I PI 3-kinase inhibitor. GSK 1059615 inhibits PI 3-kinase signaling and induces G1 arrest and apoptosis, especially in breast tumor cells. GSK 1059615 inhibits PI 3-kinase α (IC50 of 2 nM, Ki of 0.42 nM), β (Ki of 0.6 nM), γ (Ki of 0.47 nM) and δ (Ki of 1.7 nM). GSK 1059615 is also an inhibitor of mTOR (FRAP) (IC50 of 0.4-12 nM).
Inhibitor of:
AIDA, mTOR, and PI 3-kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 1059615, 10 mg | sc-361198 | 10 mg | $183.00 | |||
GSK 1059615, 50 mg | sc-361198A | 50 mg | $842.00 |