Molecular structure of GSK 0660, CAS Number: 1014691-61-2
GSK 0660 (CAS 1014691-61-2)
See product citations (14)
Alternate Names:
3-[[[2-Methoxy-4-(phenylamino)pheny l]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
Application:
GSK 0660 is a selective PPARδ antagonist
CAS Number:
1014691-61-2
Purity:
≥98%
Molecular Weight:
418.49
Molecular Formula:
C19H18N2O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.
GSK 0660 (CAS 1014691-61-2) References
- Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. | Shearer, BG., et al. 2008. Mol Endocrinol. 22: 523-9. PMID: 17975020
- The Role of PPARs in the Endothelium: Implications for Cancer Therapy. | Bishop-Bailey, D. and Swales, KE. 2008. PPAR Res. 2008: 904251. PMID: 19043612
- PPAR-delta in Vascular Pathophysiology. | Wang, N. 2008. PPAR Res. 2008: 164163. PMID: 19132133
- Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels. | Bao, XC., et al. 2014. Exp Lung Res. 40: 105-16. PMID: 24624894
- RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells. | Savage, SR., et al. 2015. Mol Vis. 21: 568-76. PMID: 26015769
- The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis. | Capozzi, ME., et al. 2020. Exp Eye Res. 190: 107885. PMID: 31758977
- PPARδ Agonist GW501516 Suppresses the TGF-β-Induced Profibrotic Response of Human Bronchial Fibroblasts from Asthmatic Patients. | Paw, M., et al. 2023. Int J Mol Sci. 24: PMID: 37175437
- Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models. | Antonosante, A., et al. 2023. Biol Res. 56: 27. PMID: 37226204
- PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury. | Qian, B., et al. 2023. Liver Int. 43: 2808-2823. PMID: 37833850
- GSK0660 enhances antitumor immunotherapy by reducing PD-L1 expression. | Khan, B., et al. 2024. Eur J Pharmacol. 972: 176565. PMID: 38599309
Inhibitor of:
ABCG8, ABHD5, acetyl-CoA acyltransferase 2 (ACAA2), Angptl7, PPAR beta, and PPARα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 0660, 10 mg | sc-203985 | 10 mg | $172.00 | |||
GSK 0660, 50 mg | sc-203985A | 50 mg | $695.00 |