GSC Antibody (L-36): sc-81964

GSC Antibody (L-36) is a mouse monoclonal IgG2a kappa light chain antibody that detects GSC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GSC antibody (L-36) is available as a non-conjugated format. Goosecoid (GSC) is a crucial homeodomain transcription factor that plays a significant role in embryonic development, particularly in the formation of the lower mandible and associated structures, including the tongue, nasal cavity, and components of the inner ear. GSC (L-36) antibody targets GSC protein primarily located in the nucleus, where GSC binds to specific DNA sequences to regulate gene expression, which is vital for proper morphogenetic processes during early development. Nuclear localization of GSC enables effective interaction with other transcription factors and regulatory proteins, ensuring accurate timing and expression of genes necessary for the development of various tissues. GSC belongs to the bicoid subfamily of the paired homeobox family, and GSC function is essential for normal embryonic patterning and organogenesis.

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GSC Antibody (L-36) References:

1. Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer.  |  Yao, J. and Kessler, DS. 2001. Development. 128: 2975-87. PMID: 11532920
2. Goosecoid and cerberus-like do not interact during mouse embryogenesis.  |  Borges, AC., et al. 2002. Int J Dev Biol. 46: 259-62. PMID: 11934155
3. Survey for paired-like homeodomain gene expression in the hypothalamus: restricted expression patterns of Rx, Alx4 and goosecoid.  |  Asbreuk, CH., et al. 2002. Neuroscience. 114: 883-9. PMID: 12379244
4. Expression patterns of fork head and goosecoid homologues in the mollusc Patella vulgata supports the ancestry of the anterior mesendoderm across Bilateria.  |  Lartillot, N., et al. 2002. Dev Genes Evol. 212: 551-61. PMID: 12459924
5. Miz1 is required for early embryonic development during gastrulation.  |  Adhikary, S., et al. 2003. Mol Cell Biol. 23: 7648-57. PMID: 14560010
6. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.  |  Namciu, SJ., et al. 2004. Mamm Genome. 15: 162-78. PMID: 15014966
7. Acceleration of early chick embryo morphogenesis by insulin is associated with altered expression of embryonic genes.  |  Patwardhan, V., et al. 2004. Int J Dev Biol. 48: 319-26. PMID: 15300512
8. Comparison of Afirma GEC and GSC to Nodules Without Molecular Testing in Cytologically Indeterminate Thyroid Nodules.  |  Polavarapu, P., et al. 2021. J Endocr Soc. 5: bvab148. PMID: 34708178
9. Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.  |  Lokumcu, T., et al. 2024. ACS Nano. 18: 2500-2519. PMID: 38207106
10. Ginseng-Sanqi-Chuanxiong (GSC) extracts attenuate d-galactose-induced vascular aging in mice via inhibition of endothelial progenitor cells senescence.  |  Liu, Y., et al. 2024. Heliyon. 10: e25253. PMID: 38404901
11. GSC: efficient lossless compression of VCF files with fast query.  |  Luo, X., et al. 2024. Gigascience. 13: PMID: 39028587
12. Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens.  |  Liu, Y., et al. 2024. Chin Med. 19: 143. PMID: 39402613

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSC Antibody (L-36) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GSC Antibody (L-36) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSC Antibody (L-36) Specifications

Alternate Product Name: GSC

Product Clone Name: L-36

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 151-258

Epitope Target: GSC

Epitope Species: human

Product Reactivity/Detection: GSC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GSC Antibody (L-36): N/A