GSA 10 (CAS 300833-95-8)

GSA 10 is a chemical compound identified as an inhibitor of GSK-3β (glycogen synthase kinase 3 beta), a kinase involved in numerous cellular processes, including cell differentiation, proliferation, and apoptosis. GSK-3β is a crucial component of various signaling pathways, most notably the Wnt and insulin signaling pathways, making it a target of significant interest in cellular and molecular biology research. The mechanism of action of GSA 10 involves the selective inhibition of GSK-3β activity. By binding to GSK-3β, GSA 10 prevents the kinase from phosphorylating its substrates, which include a variety of proteins that play roles in cell structure, function, and survival. This inhibition leads to changes in the phosphorylation status of these proteins, thereby affecting their activity and stability, and influencing cellular signaling networks. In scientific research, GSA 10 has been utilized primarily to study the role of GSK-3β in cell signaling and its implications for cell behavior. For instance, inhibiting GSK-3β with GSA 10 has allowed researchers to probe its role in the regulation of glycogen metabolism, as well as its involvement in neuronal development and function. This research is crucial for understanding the complex biological processes in which GSK-3β is involved, particularly in the context of neuronal signaling and metabolic regulation, providing insights into fundamental cellular mechanisms.