GRP 94 Antibody (2H3): sc-53929
- GRP 94 Antibody (2H3) is a mouse monoclonal IgG2a, cited in 5 publications, provided at 50 µg/500 µl
- raised against amino acids 676-803 of GRP 94 of human origin
- recommended for detection of GRP 94 of human origin by WB, IP and IF
- See GRP 94 (9G10): sc-32249 for GRP 94 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GRP 94 Antibody (2H3). This work is in progress.
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GRP 94 Antibody (2H3) is a mouse monoclonal IgG2a antibody that detects GRP 94 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GRP 94, also known as tumor rejection antigen 1 (TRA1), ECGP, and GP96, is a crucial endoplasmic reticulum (ER) chaperone that plays a significant role in protein folding and quality control within the cell. ER localization of GRP 94 ensures newly synthesized proteins achieve proper conformation before transport to final destinations, which is essential for maintaining cellular homeostasis and function. GRP 94 shows high expression in certain cancer cells, such as BGC-823 human gastric carcinoma cells, and undergoes upregulation in response to hypoxic conditions through hypoxia-inducible factor 1 (HIF-1) action. This upregulation highlights GRP 94′s importance in cancer biology, as GRP 94 may contribute to tumor survival and resistance to therapy. Anti-GRP 94 antibody (2H3) serves as an invaluable tool for researchers studying GRP 94′s role in various cellular processes and implications in diseases, particularly cancer.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRP 94 Antibody (2H3) | sc-53929 | 50 µg/500 µl | $322.00 |