Date published: 2025-12-16

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GRP (CAS 74815-57-9)

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Alternate Names:
Gastrin-releasing peptide
CAS Number:
74815-57-9
Molecular Weight:
2805.31
Molecular Formula:
C126H198N38O31S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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GRP, also known as Gastrin-releasing peptide, porcine, a neuropeptide found in the central nervous system (CNS) of mammals, belongs to the bombesin family of peptides. Its involvement in a range of physiological processes, such as the regulation of feeding behavior, thermoregulation, and stress response, has been well-established. Notably, GRP exhibits interactions with various receptors in both the CNS and peripheral tissues, including the GRP receptor, neuromedin B receptor, and gastrin-releasing peptide receptor. These interactions initiate a cascade of events, triggering the activation of multiple signaling pathways. Among these pathways, the phosphatidylinositol 3-kinase (PI3K) pathway and the mitogen-activated protein kinase (MAPK) pathway play significant roles. Such activation can have profound effects on cellular processes and contribute to the overall physiological response mediated by GRP.


GRP (CAS 74815-57-9) References

  1. Gastrin releasing peptide in the rat suprachiasmatic nucleus: an immunohistochemical, chromatographic and radioimmunological study.  |  Mikkelsen, JD., et al. 1991. Neuroscience. 40: 55-66. PMID: 2052155
  2. Gastrin-releasing peptide expression and its effect on the calcification of developing mouse incisor.  |  Lee, DJ., et al. 2015. Histochem Cell Biol. 144: 273-9. PMID: 26126650
  3. Effects of gastrin releasing peptide and its related peptides on the release of gastrin.  |  Yamashita, Y., et al. 1989. Kurume Med J. 36: 29-33. PMID: 2770221
  4. Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species-dependent migration in lung adenocarcinoma cells.  |  Jaeger, N., et al. 2017. Tumour Biol. 39: 1010428317694321. PMID: 28351312
  5. Gastrin-releasing peptide attenuates fear memory reconsolidation.  |  Murkar, A., et al. 2018. Behav Brain Res. 347: 255-262. PMID: 29191578
  6. Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice.  |  Matsumoto, Y., et al. 2018. Laryngoscope. 128: E377-E384. PMID: 30151920
  7. Gastrin-releasing peptide inhibits CA1 neurons via increasing inhibitory synaptic transmissions in hippocampal slices of rats.  |  Yao, Y., et al. 2019. Neuroreport. 30: 1048-1053. PMID: 31490840
  8. Gastrin releasing peptide-induced satiety is associated with hypothalamic and brainstem changes in chicks.  |  Bohler, M., et al. 2019. Neurosci Lett. 713: 134529. PMID: 31585210
  9. Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.  |  Park, HJ., et al. 2020. Cells. 9: PMID: 32192106
  10. The effects of gastrin-releasing peptide on the voltage-gated channels in rat hippocampal neurons.  |  Yang, J., et al. 2020. Neuropeptides. 84: 102080. PMID: 33059246
  11. Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis.  |  Choi, Y., et al. 2020. Cells. 10: PMID: 33396360
  12. Gastrin-releasing peptide in the porcine pancreas.  |  Knuhtsen, S., et al. 1987. Gastroenterology. 92: 1153-8. PMID: 3549425
  13. Characterization of the expression of gastrin-releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans.  |  Takanami, K., et al. 2022. J Comp Neurol. 530: 2804-2819. PMID: 35686563
  14. Analgesic effect of gastrin-releasing peptide in the dorsal horn.  |  Saeki, A., et al. 2022. Mol Pain. 18: 17448069221108965. PMID: 35815426
  15. Vasoactive intestinal peptide and gastrin-releasing peptide play distinct roles in the suprachiasmatic nucleus.  |  Isobe, Y. and Nishino, H. 1996. Brain Res Bull. 40: 287-90. PMID: 8842415

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GRP, 1 mg

sc-495870
1 mg
$219.00