Date published: 2025-10-15

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GROα/β/γ Antibody (m12z): sc-74247

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Datasheets
  • GROα/β/γ Antibody (m12z) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against full length recombinant GROβ of human origin
  • recommended for detection of GROα, GROβ and GROγ of human origin by WB and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GROα/β/γ Antibody (m12z). This work is in progress.

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    GROα/β/γ Antibody (m12z) is a mouse monoclonal IgG1 antibody that detects GROα/β/γ in human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). GROα/β/γ, part of the C-X-C chemokine subfamily, plays a crucial role in regulating cell motility and growth, acting as a potent chemoattractant for neutrophils and a mediator of angiogenesis. The importance of GRO proteins extends to their involvement in various physiological and pathological processes, including inflammation and tumor progression. Specifically, these chemokines are implicated in the progression of melanocytes to malignant melanoma, highlighting their potential as targets for therapeutic intervention. GROα/β/γ influences cell behavior and serves as a significant protein in cancer research and immunology, providing insights into the mechanisms of disease and potential treatment strategies. Anti-GROα/β/γ antibody (m12z) is an essential tool for researchers aiming to explore the intricate roles of these chemokines in human health and disease.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    GROα/β/γ Antibody (m12z) References:

    1. Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease.  |  Krishnaswamy, G., et al. 1999. J Interferon Cytokine Res. 19: 91-104. PMID: 10090394
    2. Chemokines in human colorectal carcinoma.  |  Baier, PK., et al. 2005. Anticancer Res. 25: 3581-4. PMID: 16101183
    3. Human astrocytes: secretome profiles of cytokines and chemokines.  |  Choi, SS., et al. 2014. PLoS One. 9: e92325. PMID: 24691121
    4. CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer.  |  Korbecki, J., et al. 2022. Int J Mol Sci. 23: PMID: 35216283
    5. Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis.  |  Mo, Y., et al. 2023. Mol Cancer. 22: 4. PMID: 36624516
    6. Circulating Inflammatory Cytokines and Female Reproductive Diseases: A Mendelian Randomization Analysis.  |  Lin, Y., et al. 2023. J Clin Endocrinol Metab. 108: 3154-3164. PMID: 37350485
    7. The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers.  |  Korbecki, J., et al. 2023. Cells. 12: PMID: 37408240
    8. Identification of potential angiogenic biomarkers in human follicular fluid for predicting oocyte maturity.  |  Chen, HT., et al. 2023. Front Endocrinol (Lausanne). 14: 1173079. PMID: 37635970
    9. Systemic Immune Factors and Risk of Allergic Contact Dermatitis: A Bidirectional Mendelian Randomization Study.  |  Long, Y., et al. 2024. Int J Mol Sci. 25: PMID: 39408763
    10. In vitro and in vivo activity and pathophysiology of human interleukin-8 and related peptides.  |  Zwahlen, R., et al. 1993. Int Rev Exp Pathol. 34 Pt B: 27-42. PMID: 8458715

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    GROα/β/γ Antibody (m12z)

    sc-74247
    100 µg/ml
    $316.00