Griseofulvin-13C,d3 (CAS 126-07-8 (unlabeled))

Griseofulvin-13C,d3 is a labeled analog of griseofulvin, a naturally occurring antifungal compound derived from the fungus Penicillium griseofulvum. This particular derivative is enriched with the stable isotopes carbon-13 (13C) and deuterium (D3), enhancing its utility in advanced research methodologies, particularly in the study of metabolic pathways and molecular interactions through techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Griseofulvin itself functions by binding to microtubules, thereby disrupting the mitotic spindle formation and inhibiting fungal cell division. This action effectively prevents the replication of fungal cells at the phase of mitosis, specifically targeting the polymerization dynamics of tubulin. The incorporation of isotopic labels (13C and D3) in griseofulvin enhances its detection and quantification in biological samples, allowing researchers to trace its distribution, metabolism, and excretion in biological systems with high precision. This isotopically labeled version does not alter the intrinsic antifungal mechanism of the parent compound but provides a powerful tool for elucidating the pharmacokinetic profiles and metabolic pathways in fungicidal research, aiding in the detailed mapping of its action and interaction within the cellular environment. Such studies are crucial for developing a deeper understanding of how such compounds behave in complex biological matrices, contributing significantly to the fields of mycology and pharmacology.