GRIP1 Antibody (32): sc-135931
- GRIP1 Antibody (32) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 877-1067 of GRIP1 of rat origin
- recommended for detection of GRIP1 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GRIP1 Antibody (32). This work is in progress.
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GRIP1 Antibody (32) is a mouse monoclonal IgG1 antibody that detects GRIP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GRIP1, a member of the PDZ domain-containing protein family, plays a crucial role in synaptic transmission by interacting with AMPA receptor subunits, specifically GluR-2 and GluR-3, facilitating their localization to the synapse. This localization is vital for proper synaptic function and plasticity, as GRIP1 influences the strength and efficacy of excitatory neurotransmission in the brain. GRIP1 is predominantly expressed in the cerebral cortex, hippocampus, and olfactory bulb, with expression beginning in early development before the appearance of AMPA receptors, highlighting GRIP1′s importance in neural development. Additionally, GRIP1 is involved in the regulation of receptor endocytosis, particularly in response to phosphorylation events that are critical for processes such as cerebellar long-term depression. GRIP1′s ability to modulate the synaptic presence of AMPA receptors underscores GRIP1′s significance in both normal brain function and the pathophysiology of neurodegenerative diseases. Anti-GRIP1 antibody (32) is an essential tool for researchers studying synaptic dynamics and the molecular mechanisms underlying neural plasticity.
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GRIP1 Antibody (32) References:
- The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. | Baumann, CT., et al. 2001. Mol Endocrinol. 15: 485-500. PMID: 11266502
- Regulation of GRIP1 and CBP Coactivator activity by Rho GDI modulates estrogen receptor transcriptional enhancement. | Su, LF., et al. 2002. J Biol Chem. 277: 37037-44. PMID: 12138084
- Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. | Liao, L., et al. 2002. J Steroid Biochem Mol Biol. 83: 3-14. PMID: 12650696
- Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer. | Gregory, CW., et al. 2004. J Biol Chem. 279: 7119-30. PMID: 14662770
- GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor. | Shen, HC., et al. 2005. Biol Chem. 386: 69-74. PMID: 15843149
- Interaction of beta-catenin and TIF2/GRIP1 in transcriptional activation by the androgen receptor. | Song, LN. and Gelmann, EP. 2005. J Biol Chem. 280: 37853-67. PMID: 16141201
- AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. | Duong, BN., et al. 2006. Cancer Res. 66: 8373-81. PMID: 16951146
- cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. | Hoang, T., et al. 2013. Endocrinology. 154: 1513-27. PMID: 23462962
- Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression. | Zhang, W., et al. 2016. Mol Nutr Food Res. 60: 2387-2395. PMID: 27342949
- Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. | Khanal, T., et al. 2017. Sci Rep. 7: 10662. PMID: 28878246
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRIP1 Antibody (32) | sc-135931 | 50 µg/0.5 ml | $316.00 |