Grifolic Acid (CAS 80557-12-6)
Alternate Names:
2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]benzoic Acid; (E,E)-2,4-dihydroxy-6-methyl-3-(3,7,11- trimethyl-2,6,10-dodecatrienyl)benzoic Acid; 2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzoic Acid
CAS Number:
80557-12-6
Molecular Weight:
372.5
Molecular Formula:
C23H32O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Grifolic acid is a naturally occurring compound found in various plants, including the Grifola frondosa mushroom. As a relatively recent discovery, the full scope of grifolic acid′s potential is still under investigation. Grifolic acid appears to operate through several mechanisms, demonstrating the ability to modulate the expression of inflammatory mediators, such as cytokines and chemokines. It has also been observed to influence the expression of cell surface receptors, including toll-like receptors and adhesion molecules. Additionally, grifolic acid is believed to affect the activity of enzymes participating in signal transduction pathways, like protein kinases and phosphatases.
Grifolic Acid (CAS 80557-12-6) References
- Novel selective ligands for free fatty acid receptors GPR120 and GPR40. | Hara, T., et al. 2009. Naunyn Schmiedebergs Arch Pharmacol. 380: 247-55. PMID: 19471906
- Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | Janssen, S., et al. 2012. PLoS One. 7: e40168. PMID: 22768248
- Total Synthesis of Grifolin, Grifolic Acid, LL-Z1272α, LL-Z1272β, and Ilicicolinic Acid A. | Grabovyi, GA. and Mohr, JT. 2016. Org Lett. 18: 5010-5013. PMID: 27647101
- Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue. | Okada, M., et al. 2017. Org Lett. 19: 3183-3186. PMID: 28541042
- Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis. | Iijima, M., et al. 2017. Plant Physiol. 174: 2213-2230. PMID: 28679557
- Grifolic acid induces mitochondrial membrane potential loss and cell death of RAW264.7 macrophages. | Zhao, Y., et al. 2018. Mol Med Rep. 17: 3281-3287. PMID: 29257254
- Daurichromenic acid and grifolic acid: Phytotoxic meroterpenoids that induce cell death in cell culture of their producer Rhododendron dauricum. | Taura, F., et al. 2018. Plant Signal Behav. 13: e1422463. PMID: 29286881
- Grifolic acid causes osteosarcoma cell death in vitro and in tumor-bearing mice. | Zhao, YF., et al. 2018. Biomed Pharmacother. 103: 1035-1042. PMID: 29710661
- Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through a GPR120-independent mechanism. | Zhao, Y., et al. 2018. BMC Pharmacol Toxicol. 19: 26. PMID: 29843779
- An Aromatic Farnesyltransferase Functions in Biosynthesis of the Anti-HIV Meroterpenoid Daurichromenic Acid. | Saeki, H., et al. 2018. Plant Physiol. 178: 535-551. PMID: 30097469
- Mitochondrial Dysfunction Pathway Networks and Mitochondrial Dynamics in the Pathogenesis of Pituitary Adenomas. | Li, N. and Zhan, X. 2019. Front Endocrinol (Lausanne). 10: 690. PMID: 31649621
- Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity. | Akiba, M., et al. 2020. Bioorg Med Chem Lett. 30: 126808. PMID: 31791817
- Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom Albatrellus yasudae. | Masuda, Y., et al. 2021. J Nat Prod. 84: 1748-1754. PMID: 34100599
Activator of:
GPR120.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grifolic Acid, 1 mg | sc-490334 | 1 mg | $312.00 |