granzyme B Antibody (GB7): sc-56119
- granzyme B Antibody (GB7) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 100 µg/ml
- raised against full length granzyme B of human origin
- recommended for detection of granzyme B of human origin by WB, IP, IF and IHC(P)
- See granzyme B (2C5): sc-8022 for granzyme B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for granzyme B Antibody (GB7). This work is in progress.
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Granzyme B Antibody (GB7) is a mouse monoclonal IgG2a light chain antibody that detects granzyme B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-granzyme B antibody (GB7) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. Granzyme B plays a crucial role in the immune response, particularly in the induction of apoptosis in target cells, which is essential for maintaining immune homeostasis and eliminating infected or malignant cells. This serine protease is primarily located within cytolytic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, where granzyme B is stored as an inactive proenzyme until release during degranulation. Upon activation, granzyme B cleaves and activates caspases, such as caspase-3, caspase-6, caspase-7, and caspase-9, leading to a cascade of events that culminate in programmed cell death. The precise localization of granzyme B within cytolytic granules ensures direct delivery to target cells during immune responses, enhancing the efficiency of apoptosis induction. Understanding granzyme B function and localization is critical for developing therapeutic strategies aimed at modulating immune responses in various diseases, including cancer and autoimmune disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
granzyme B Antibody (GB7) References:
- Granzyme B-induced cell death. | Andrade, F., et al. 2004. Acta Haematol. 111: 28-41. PMID: 14646343
- Granzyme B as a novel factor involved in cardiovascular diseases. | Saito, Y., et al. 2011. J Cardiol. 57: 141-7. PMID: 21168312
- Granzyme B in skin inflammation and disease. | Turner, CT., et al. 2019. Matrix Biol. 75-76: 126-140. PMID: 29247692
- Pathological functions of granzyme B in inflammatory skin diseases. | Hiroyasu, S., et al. 2021. J Dermatol Sci. 104: 76-82. PMID: 34772583
- Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes. | Jamann, H., et al. 2022. Front Immunol. 13: 850616. PMID: 35479072
- NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection. | Lim, YS., et al. 2023. Cell Rep. 42: 112410. PMID: 37071533
- Imaging and monitoring of granzyme B in the immune response. | Li, X., et al. 2024. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 16: e1928. PMID: 37715320
- Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization. | Obasanmi, G., et al. 2024. Angiogenesis. 27: 351-373. PMID: 38498232
- Granzyme B in aging and age-related pathologies. | Richardson, KC., et al. 2024. Trends Mol Med. 30: 1165-1179. PMID: 39181801
- Granzyme B PET/CT Imaging Evaluates Early Response to Immunotherapy in Gastric Cancer. | Liu, Q., et al. 2024. J Nucl Med. 65: 1695-1701. PMID: 39389628
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
granzyme B Antibody (GB7) | sc-56119 | 100 µg/ml | $322.00 |