Granulocytes Antibody (HIS48): sc-19613

Granulocytes Antibody (HIS48) is a mouse monoclonal IgM kappa light chain antibody that detects Granulocytes protein of mouse and rat origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Granulocytes Antibody (HIS48) is available in non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). Granulocytes play a crucial role in the immune system, particularly in innate immune response, where these cells act as the first line of defense against pathogens. Granulocytes are characterized by dense cytoplasmic granules, which contain enzymes and antimicrobial substances essential for combating infections. Granulocytes are derived from myeloid progenitor cells in bone marrow and include three main types: basophils, eosinophils, and neutrophils. Each type has a specific function; neutrophils are the most abundant leukocytes and are vital for phagocytosing bacteria and fungi, while eosinophils are particularly important in responding to parasitic infections and modulating allergic reactions. Granulocytes′ ability to migrate to sites of infection and inflammation underscores their importance in maintaining homeostasis and orchestrating immune responses. Granulocytes Antibody (HIS48) enables researchers to effectively study the dynamics and functions of these critical immune cells in various experimental settings.

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Granulocytes Antibody (HIS48) References:

1. Aging and innate immune cells.  |  Plackett, TP., et al. 2004. J Leukoc Biol. 76: 291-9. PMID: 15039467
2. Chemokine receptors and leukocyte trafficking in the mucosal immune system.  |  Williams, IR. 2004. Immunol Res. 29: 283-92. PMID: 15181289
3. In vivo imaging of leukocyte trafficking in blood vessels and tissues.  |  Mempel, TR., et al. 2004. Curr Opin Immunol. 16: 406-17. PMID: 15245733
4. Interactions between the innate immune and blood coagulation systems.  |  Esmon, CT. 2004. Trends Immunol. 25: 536-42. PMID: 15364056
5. Chemokines: control of primary and memory T-cell traffic.  |  Schaerli, P. and Moser, B. 2005. Immunol Res. 31: 57-74. PMID: 15591623
6. Immune traffic: a functional overview.  |  Beilhack, A. and Rockson, SG. 2003. Lymphat Res Biol. 1: 219-34. PMID: 15624439
7. Leukocyte adhesion: what's the catch?  |  Hammer, DA. 2005. Curr Biol. 15: R96-9. PMID: 15694300
8. The macrophage as a secretory cell in chronic inflammation.  |  Davies, P. and Allison, AC. 1976. Agents Actions. 6: 60-74. PMID: 181971

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Granulocytes Antibody (HIS48) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-Granulocytes Antibody (HIS48) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Granulocytes Antibody (HIS48) Specifications

Alternate Product Name: Granulocytes

Product Clone Name: HIS48

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Granulocytes

Epitope Species: rat

Product Reactivity/Detection: an antigen found on all granulocytes, also found on cells of the erythoid lineage at various stages of maturations in bone marrow

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for Granulocytes Antibody (HIS48): FITC: Fluoroscein, PE: Phycoerythrin