Molecular structure of Granisetron hydrochloride, CAS Number: 107007-99-8
Granisetron hydrochloride (CAS 107007-99-8)
Alternate Names:
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Application:
Granisetron hydrochloride is a SR-3 antagonist
CAS Number:
107007-99-8
Purity:
≥98%
Molecular Weight:
348.87
Molecular Formula:
C18H24N4O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Granisetron hydrochloride is a selective 5-HT3 receptor antagonist that functions by competitively binding to the 5-HT3 receptor site on the post-synaptic neurons in the central and peripheral nervous systems. This binding inhibits the action of serotonin, a neurotransmitter that plays a role in the initiation of vomiting. By blocking the 5-HT3 receptors, granisetron hydrochloride effectively prevents the initiation of the vomiting reflex. Granisetron Hydrochloride′s mechanism of action involves the inhibition of serotonin binding to the 5-HT3 receptors, thereby reducing the likelihood of vomiting. Granisetron hydrochloride′s function in experimental applications involves its ability to target and block the 5-HT3 receptors, thereby preventing the initiation of the vomiting reflex at the molecular level.
Granisetron hydrochloride (CAS 107007-99-8) References
- [Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography]. | Deng, GF. and Yao, TW. 2008. Zhejiang Da Xue Xue Bao Yi Xue Ban. 37: 156-8. PMID: 18422275
- Development and application of a validated stability-indicating HPLC method for simultaneous determination of granisetron hydrochloride, benzyl alcohol and their main degradation products in parenteral dosage forms. | Hewala, I., et al. 2010. Talanta. 82: 184-95. PMID: 20685455
- Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride. | Zheng, WW., et al. 2010. Chem Pharm Bull (Tokyo). 58: 1015-9. PMID: 20686252
- First derivative spectrophotometric determination of granisetron hydrochloride in presence of its hydrolytic products and preservative and application to pharmaceutical preparations. | Hewala, II., et al. 2013. Drug Test Anal. 5: 234-41. PMID: 22290876
- Provesicular granisetron hydrochloride buccal formulations: in vitro evaluation and preliminary investigation of in vivo performance. | Ahmed, S., et al. 2014. Eur J Pharm Sci. 60: 10-23. PMID: 24793896
- Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Granisetron Hydrochloride. | Wu, G., et al. 2018. Int J Pharm Compd. 22: 86-94. PMID: 29385389
- Compatibility and Stability of Nab-Paclitaxel in Combination with Other Drugs. | Mizuta, N., et al. 2017. Kobe J Med Sci. 63: E9-E16. PMID: 29434168
- Compatibility and stability of methylprednisolone sodium succinate and granisetron hydrochloride in 0.9% sodium chloride solution. | Guo, Z., et al. 2022. Medicine (Baltimore). 101: e29674. PMID: 35839031
- Stability of granisetron hydrochloride in a disposable elastomeric infusion device. | Chung, KC., et al. 1995. Am J Health Syst Pharm. 52: 1541-3. PMID: 7552896
- Stability of granisetron hydrochloride with dexamethasone sodium phosphate for 14 days. | Chin, A., et al. 1996. Am J Health Syst Pharm. 53: 1174-6. PMID: 8734682
- Stability and compatibility of granisetron hydrochloride in i.v. solutions and oral liquids and during simulated Y-site injection with selected drugs. | Mayron, D. and Gennaro, AR. 1996. Am J Health Syst Pharm. 53: 294-304. PMID: 8808027
- Stability of granisetron hydrochloride in polypropylene syringes. | Quercia, RA., et al. 1996. Am J Health Syst Pharm. 53: 2744-6. PMID: 8931820
- Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration. | Trissel, LA., et al. 1997. Am J Health Syst Pharm. 54: 56-60. PMID: 9117791
- Stability of granisetron hydrochloride in two oral suspensions. | Nahata, MC., et al. 1998. Am J Health Syst Pharm. 55: 2511-3. PMID: 9853637
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SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Granisetron hydrochloride, 10 mg | sc-203984 | 10 mg | $128.00 | |||
Granisetron hydrochloride, 50 mg | sc-203984A | 50 mg | $530.00 |