Molecular structure of Gramicidin A, CAS Number: 11029-61-1
Gramicidin A (CAS 11029-61-1)
See product citations (7)
Alternate Names:
Gramicidin A is also known as Valyl gramicidin A.
Application:
Gramicidin A is an effective and naturally occurring antibiotic against Gram positive organisms, used to study membrane channels.
CAS Number:
11029-61-1
Purity:
≥90%
Molecular Weight:
1882.29
Molecular Formula:
C99H140N20O17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gramicidin A is an antibiotic that is a naturally occurring ion channel-forming pentadecapeptide. Bacillus brevis produces Gramicidin A and is an effective antibiotic against Gram positive organisms. Gramicidin A can be used to study membrane channels because of its cation-selective, single-filing pore. Gramicidin A has been used as a model to study ion channel proteins, and acylation of membrane proteins. The Gramicidin A channel has demonstrated to be permeable to small monovalent cations, protons, and water but impermeable to divalent cations and anions.
Gramicidin A (CAS 11029-61-1) References
- Purification of gramicidin A. | Stankovic, CJ., et al. 1990. Anal Biochem. 184: 100-3. PMID: 1690956
- Co-crystals of gramicidin A and phospholipid. A system for studying the structure of a transmembrane channel. | Wallace, BA. and Janes, RW. 1991. J Mol Biol. 217: 625-7. PMID: 1706436
- Gramicidin A directly inhibits mammalian Na(+)/K (+)-ATPase. | Takada, Y., et al. 2008. Mol Cell Biochem. 319: 99-103. PMID: 18622737
- THE PRODUCTION OF BACTERICIDAL SUBSTANCES BY AEROBIC SPORULATING BACILLI. | Dubos, RJ. and Hotchkiss, RD. 1941. J Exp Med. 73: 629-40. PMID: 19871101
- Structure of gramicidin A. | Wallace, BA. 1986. Biophys J. 49: 295-306. PMID: 2420381
- Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. | David, JM., et al. 2014. Mol Cancer Ther. 13: 788-99. PMID: 24493697
- The antimicrobial activity of gramicidin A is associated with hydroxyl radical formation. | Liou, JW., et al. 2015. PLoS One. 10: e0117065. PMID: 25622083
- The Effect of Calcium and Halide Ions on the Gramicidin A Molecular State and Antimicrobial Activity. | Carillo, KD., et al. 2020. Int J Mol Sci. 21: PMID: 32867026
- Gramicidin A is hydrolyzed by a d-stereospecific peptidase produced by Bacillus anthracis. | Kaman, WE., et al. 2022. Environ Microbiol Rep. 14: 570-576. PMID: 35403341
- Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A. | Fang, ST., et al. 2022. Biomolecules. 12: PMID: 36551225
- Palmitoylation-induced conformational changes of specific side chains in the gramicidin transmembrane channel. | Koeppe, RE., et al. 1995. Biochemistry. 34: 9299-306. PMID: 7542918
- The permeation properties of small organic cations in gramicidin A channels. | Seoh, SA. and Busath, D. 1993. Biophys J. 64: 1017-28. PMID: 7684267
- Two mechanisms of H+/OH- transport across phospholipid vesicular membrane facilitated by gramicidin A. | Prabhananda, BS. and Kombrabail, MH. 1996. Biophys J. 71: 3091-7. PMID: 8968580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gramicidin A, 1 mg | sc-203061 | 1 mg | $80.00 | |||
Gramicidin A, 5 mg | sc-203061A | 5 mg | $148.00 |