Molecular structure of GR 135531, CAS Number: 190277-13-5
GR 135531 (CAS 190277-13-5)
Alternate Names:
5-Methoxycarbonylamino-N-acetyltryptamine
Application:
GR 135531 is an agonist of the melatonin MT3 receptors
CAS Number:
190277-13-5
Molecular Weight:
275.31
Molecular Formula:
C14H17N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GR 13553 is a compound that falls within the tryptamine category. This substance is found in the venom of the Colorado River toad (Bufo alvarius) and shares a structural similarity with serotonin, a key neurotransmitter in the human body. Studies have explored GR 135531 for its role in promoting neuroplasticity, potentially offering insights into the management of neurological conditions. GR 135531 is a putative MEL-1 (melatonin MT3 receptor) agonist, showing low affinity for melatonin receptors MEL-1A-R and MEL-1B-R. Since GR 135531 binds to MT3 with such high affinity, this compound can be used to discriminate between the melatonin receptor subtypes (MEL-1A-R, MEL-1B-R, and MEL-1(MT3)).
GR 135531 (CAS 190277-13-5) References
- Negative regulation of cytosolic phospholipase A(2) by melatonin in the rat pineal gland. | Li, B., et al. 2000. Biochem J. 351 Pt 3: 709-16. PMID: 11042126
- Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits. | Pintor, J., et al. 2001. Eur J Pharmacol. 416: 251-4. PMID: 11290376
- Expression and functional characterization of the mt1 melatonin receptor from rat brain in Xenopus oocytes: evidence for coupling to the phosphoinositol pathway. | Blumenau, C., et al. 2001. J Pineal Res. 30: 139-46. PMID: 11316324
- Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes. | Brydon, L., et al. 2001. Endocrinology. 142: 4264-71. PMID: 11564683
- Presence of diadenosine polyphosphates in the aqueous humor: their effect on intraocular pressure. | Pintor, J., et al. 2003. J Pharmacol Exp Ther. 304: 342-8. PMID: 12490610
- Differential effects of lipopolysaccharide on lipid peroxidation in F344N, SHR rats and BALB/c mice, and protection of melatonin and NAS against its toxicity. | Requintina, PJ. and Oxenkrug, GF. 2003. Ann N Y Acad Sci. 993: 325-33; discussion 345-9. PMID: 12853324
- Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum. | Escames, G., et al. 2004. J Neuroendocrinol. 16: 929-35. PMID: 15584934
- Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. | García-Navarro, A., et al. 2007. J Pineal Res. 43: 195-205. PMID: 17645698
- Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception. | Yoon, MH., et al. 2008. Life Sci. 83: 845-50. PMID: 19000700
- Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand. | Vincent, L., et al. 2010. J Pineal Res. 48: 222-229. PMID: 20210850
- Update in glaucoma medicinal chemistry: emerging evidence for the importance of melatonin analogues. | Crooke, A., et al. 2012. Curr Med Chem. 19: 3508-22. PMID: 22709004
- Melatonin receptors: are there multiple subtypes? | Dubocovich, ML. 1995. Trends Pharmacol Sci. 16: 50-6. PMID: 7762083
- Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. | Lucchelli, A., et al. 1997. Br J Pharmacol. 121: 1775-81. PMID: 9283717
- Characterization of a melatonin binding site in Siberian hamster brown adipose tissue. | Le Gouic, S., et al. 1997. Eur J Pharmacol. 339: 271-8. PMID: 9473145
Inhibitor of:
MEL-1B-R.Activator of:
MEL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GR 135531, 10 mg | sc-203981 | 10 mg | $320.00 | |||
GR 135531, 50 mg | sc-203981A | 50 mg | $1400.00 |