GR 113808 (CAS 144625-51-4)
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GR 113808 is a selective and potent antagonist of the 5-HT4 receptor. It functions by binding to the 5-HT4 receptor and inhibiting the activation of the receptor by serotonin. Gr 113808′s mechanism of action involves blocking the effects of serotonin at the 5-HT4 receptor, thereby preventing the downstream signaling pathways associated with receptor activation. By doing so, GR 113808 effectively modulates the activity of the 5-HT4 receptor, influencing cellular responses and physiological processes regulated by this receptor. Gr 113808′s function in experimental applications involves studying the specific role of the 5-HT4 receptor in various biological processes and understanding the impact of receptor modulation on cellular signaling pathways. In development applications, GR 113808 is utilized to investigate the molecular mechanisms underlying 5-HT4 receptor activation and its implications for physiological functions.
GR 113808 (CAS 144625-51-4) References
- Central 5-HT(4) receptors and drinking behavior. | Castro, L., et al. 2000. Pharmacol Biochem Behav. 66: 443-8. PMID: 10880703
- 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study. | Prins, NH., et al. 2001. Br J Pharmacol. 132: 1941-7. PMID: 11309267
- Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia. | Castro, L., et al. 2001. Braz J Med Biol Res. 34: 791-6. PMID: 11378670
- Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. | Prins, NH., et al. 2001. Br J Pharmacol. 134: 1351-9. PMID: 11704657
- Enhancement of the intrinsic defecation reflex by mosapride, a 5-HT4 agonist, in chronically lumbosacral denervated guinea pigs. | Kojima, Y., et al. 2006. J Smooth Muscle Res. 42: 139-47. PMID: 17159330
- Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle. | Nguyen, TT., et al. 2015. Pharmazie. 70: 183-92. PMID: 25980179
- 5-HT4 receptors facilitate cholinergic neurotransmission throughout the murine gastrointestinal tract. | Pauwelyn, V. and Lefebvre, RA. 2017. Neurogastroenterol Motil. 29: PMID: 28332745
- Activation and blockade of dorsal hippocampal serotonin4 receptors produce antidepressant effects in the hemiparkinsonian rats. | Wang, JW., et al. 2021. Brain Res. 147426. PMID: 33737063
- Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. | Tam, FS., et al. 1995. Br J Pharmacol. 115: 172-6. PMID: 7647972
- Antagonists of 5-HT4 receptor-mediated responses in adult hippocampal neurons. | Torres, GE., et al. 1994. J Pharmacol Exp Ther. 271: 255-61. PMID: 7965722
- Evidence for the involvement of 5-hydroxytryptamine 4 receptors in 5-hydroxytryptophan-induced diarrhea in mice. | Hedge, SS., et al. 1994. J Pharmacol Exp Ther. 271: 741-7. PMID: 7965791
- Blockade of human atrial 5-HT4 receptors by GR 113808. | Kaumann, AJ. 1993. Br J Pharmacol. 110: 1172-4. PMID: 8298805
- Intranigral GR-113808, a selective 5-HT4 receptor antagonist, attenuates morphine-stimulated dopamine release in the rat striatum. | Pozzi, L., et al. 1995. Brain Res. 692: 265-8. PMID: 8548313
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GR 113808, 10 mg | sc-361189 | 10 mg | $189.00 | |||
GR 113808, 50 mg | sc-361189A | 50 mg | $809.00 |