Molecular structure of GP-pNA, Chromogenic Substrate, CAS Number: 103213-34-9
GP-pNA, Chromogenic Substrate (CAS 103213-34-9)
Alternate Names:
Gly-Pro p-nitroanilide hydrochloride
Application:
GP-pNA, Chromogenic Substrate is a chromogenic substrate for dipeptidyl peptidase IV
CAS Number:
103213-34-9
Purity:
≥97%
Molecular Weight:
328.75
Molecular Formula:
C13H16N4O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GP-pNA, Chromogenic Substrate is a chromogenic substrate for CD26 (dipeptidyl peptidase IV, DPIV, DPPIV), DPP7/II, DPRP1 (DPP8), DPRP2 (DPP9), FAP, Angiotensinase C (PCP/PRCP), PREP/POP, and likely other prolyl peptidases. GP-pNA, Chromogenic Substrate has been employed in vitro for inhibitor screening, on cultured cells, and in biological fluids. Hydrolysis of GP-pNA, Chromogenic Substrate can be monitored at 405-410 nm.
GP-pNA, Chromogenic Substrate (CAS 103213-34-9) References
- Decreased dipeptidyl peptidase IV enzyme activity of plasma soluble CD26 and its inverse correlation with HIV-1 RNA in HIV-1 infected individuals. | Hosono, O., et al. 1999. Clin Immunol. 91: 283-95. PMID: 10370373
- Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. | Wang, M., et al. 2002. J Gastroenterol Hepatol. 17: 66-71. PMID: 11895555
- Dipeptidyl peptidase IV (CD26) activity in the hematopoietic system: differences between the membrane-anchored and the released enzyme activity. | Pereira, DA., et al. 2003. Braz J Med Biol Res. 36: 567-78. PMID: 12715075
- Characterization of dipeptidyl peptidase IV (CD26) from human lymphocytes. | De Meester, I., et al. 1992. Clin Chim Acta. 210: 23-34. PMID: 1358482
- N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding. | Aertgeerts, K., et al. 2004. Protein Sci. 13: 145-54. PMID: 14691230
- Recombinant prolylcarboxypeptidase activates plasma prekallikrein. | Shariat-Madar, Z., et al. 2004. Blood. 103: 4554-61. PMID: 14996700
- Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). | Maes, MB., et al. 2005. Biochem J. 386: 315-24. PMID: 15487984
- Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. | Bjelke, JR., et al. 2006. Biochem J. 396: 391-9. PMID: 16475979
- Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors. | Tsai, TY., et al. 2006. Bioorg Med Chem Lett. 16: 3268-72. PMID: 16581245
- Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP). | Haffner, CD., et al. 2008. Bioorg Med Chem Lett. 18: 4360-3. PMID: 18606544
- Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α. | Keane, FM., et al. 2011. FEBS J. 278: 1316-32. PMID: 21314817
- Extraction and characterization of novel multifunctional peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities. | Kula, E., et al. 2020. J Food Biochem. 44: e13179. PMID: 32153045
Substrate of:
Angiotensinase C, CD26, Chromogenic, DPP7, DPRP1, DPRP2, FAP, and PREP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GP-pNA, Chromogenic Substrate, 25 mg | sc-201156 | 25 mg | $194.00 |