Molecular structure of GP-AMC, Fluorogenic Substrate, CAS Number: 115035-46-6
GP-AMC, Fluorogenic Substrate (CAS 115035-46-6)
Alternate Names:
Gly-Pro-7-amido-4-methylcoumarin hydrobromide; Gly-Pro-AMC
Application:
GP-AMC, Fluorogenic Substrate is used to study the activity of CD26, DPP7, DPP8, FAP, and PREP
CAS Number:
115035-46-6
Purity:
>97%
Molecular Weight:
410.3
Molecular Formula:
C17H19N3O4•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GP-AMC, Fluorogenic Substrate is a substrate with an excitation at 380 nm and emission at 460 nm. The substrate has been used to study the activity of CD26 (DPIV and DPPIV), DPP7 (DPPII/VII), DPRP1 (DPP8), DPRP2 (DPP9), FAP (fibroblast activation protein), and POP/PREP. The compound has been used in a peptide assay where the release of AMC was monitored as well as in in vitro inhibtior screening.
GP-AMC, Fluorogenic Substrate (CAS 115035-46-6) References
- Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase. | Saric, T., et al. 2001. J Biol Chem. 276: 36474-81. PMID: 11479311
- Substrate specificity, inhibition and enzymological analysis of recombinant human glutamate carboxypeptidase II. | Barinka, C., et al. 2002. J Neurochem. 80: 477-87. PMID: 11905994
- Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. | Leiting, B., et al. 2003. Biochem J. 371: 525-32. PMID: 12529175
- 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. | Villhauer, EB., et al. 2003. J Med Chem. 46: 2774-89. PMID: 12801240
- Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme. | Bär, J., et al. 2003. Biol Chem. 384: 1553-63. PMID: 14719797
- Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors. | Ashton, WT., et al. 2004. Bioorg Med Chem Lett. 14: 859-63. PMID: 15012982
- Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors. | Venäläinen, JI., et al. 2006. Biochem Pharmacol. 71: 683-92. PMID: 16405869
- Antidiabetic, Antiglycation, and Antioxidant Activities of Ethanolic Seed Extract of Passiflora edulis and Piceatannol In Vitro. | Dos Santos, FAR., et al. 2022. Molecules. 27: PMID: 35807309
- In Vivo and In Vitro Comparison of the DPP-IV Inhibitory Potential of Food Proteins from Different Origins after Gastrointestinal Digestion. | Fleury, L., et al. 2022. Int J Mol Sci. 23: PMID: 35955493
Substrate of:
CD26, DPP7, DPRP1, DPRP2, Enzyme, FAP, Fluorogenic, Peptide, POP, and PREP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GP-AMC, Fluorogenic Substrate, 5 mg | sc-201157 | 5 mg | $133.00 |