Date published: 2026-3-27

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Gö 6976 (CAS 136194-77-9)

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Alternate Names:
12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
Application:
Gö 6976 is an inhibitor of certain forms of PKC, Trks, and JAKs
CAS Number:
136194-77-9
Purity:
≥99%
Molecular Weight:
378.43
Molecular Formula:
C24H18N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Go-6976, a small molecule inhibitor, specifically targets and inhibits protein kinase C (PKC) activity. PKC is responsible for regulating a wide range of cellular processes. By binding to the active site of PKC, Go-6976 effectively prevents the enzyme from carrying out its functions, leading to the inhibition of the cellular processes regulated by PKC.


Gö 6976 (CAS 136194-77-9) References

  1. Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.  |  Behrens, MM., et al. 1999. J Neurochem. 72: 919-24. PMID: 10037462
  2. Regulation of LPA receptor function by estrogens.  |  González-Arenas, A., et al. 2008. Biochim Biophys Acta. 1783: 253-62. PMID: 18166159
  3. Novel regulation of protein kinase C-η.  |  Pal, D., et al. 2012. Biochem Biophys Res Commun. 425: 836-41. PMID: 22892130
  4. Noncovalent wild-type-sparing inhibitors of EGFR T790M.  |  Lee, HJ., et al. 2013. Cancer Discov. 3: 168-81. PMID: 23229345
  5. Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes.  |  Robinson, KA., et al. 2014. PLoS One. 9: e108963. PMID: 25330241
  6. Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis.  |  Liu, J., et al. 2017. Biomed Res Int. 2017: 2957538. PMID: 28127553
  7. Evidence that PKCα inhibition in Dalton's Lymphoma cells augments cell cycle arrest and mitochondrial-dependent apoptosis.  |  Singh, RK., et al. 2022. Leuk Res. 113: 106772. PMID: 35016128
  8. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro.  |  Qatsha, KA., et al. 1993. Proc Natl Acad Sci U S A. 90: 4674-8. PMID: 7685108
  9. N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions.  |  Wenzel-Seifert, K., et al. 1994. Biochem Biophys Res Commun. 200: 1536-43. PMID: 8185608
  10. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.  |  Martiny-Baron, G., et al. 1993. J Biol Chem. 268: 9194-7. PMID: 8486620
  11. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.  |  Gschwendt, M., et al. 1996. FEBS Lett. 392: 77-80. PMID: 8772178
  12. Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Gö 6976 and Ro 31-8220 as Pkc inhibitors.  |  Harris, TE., et al. 1996. Biochem Biophys Res Commun. 227: 672-6. PMID: 8885992
  13. Protein kinase C signalling in pancreatic beta-cells: cellular and molecular approaches.  |  Persaud, SJ. 1997. Digestion. 58 Suppl 2: 86-92. PMID: 9302497

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Gö 6976, 500 µg

sc-221684
500 µg
$227.00