Date published: 2025-10-5

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Gonadotropin Antibody (ME-105): sc-57186

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Datasheets
  • Gonadotropin Antibody (ME-105) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against Gonadotropin of human origin
  • recommended for detection of Gonadotropin of human origin by ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gonadotropin Antibody (ME-105). This work is in progress.

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    Gonadotropin Antibody (ME-105) is a mouse monoclonal IgG1 antibody that detects Gonadotropin of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-Gonadotropin antibody (ME-105) is available as the non-conjugated form. Gonadotropin, also known as choriogonadotropin, plays a crucial role in early pregnancy as it is produced by the placenta during the first trimester. This hormone exists as a heterodimer, consisting of a common α chain and a unique β chain, with the latter providing biological specificity to other hormones such as thyrotropin, lutropin, and follitropin. The α subunit is encoded by a gene located on human chromosome 6, while the β subunit is found on chromosome 19. Gonadotropin stimulates the ovaries to produce and maintain essential steroid hormones, including estrogen and progesterone, which are vital for sustaining pregnancy. Additionally, Gonadotropin is classified within the cystine knot growth-factor superfamily, characterized by a unique arrangement of six cysteine residues, which is significant for structural integrity and biological function. The proper secretion and dimerization of Gonadotropin depend on the conformation of the cystine knot, although biological activity remains unaffected by this conformation. Anti-Gonadotropin antibody (ME-105) serves as an invaluable tool for researchers studying reproductive biology and hormonal changes during pregnancy.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Gonadotropin Antibody (ME-105) References:

    1. Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse.  |  Naylor, SL., et al. 1983. Somatic Cell Genet. 9: 757-70. PMID: 6581542
    2. The cystine-knot growth-factor superfamily.  |  Sun, PD. and Davies, DR. 1995. Annu Rev Biophys Biomol Struct. 24: 269-91. PMID: 7663117
    3. Mutagenesis of cysteine residues in the human gonadotropin alpha subunit. Roles of individual disulfide bonds in secretion, assembly, and biologic activity.  |  Furuhashi, M., et al. 1994. J Biol Chem. 269: 25543-8. PMID: 7929256
    4. Crystal structure of human chorionic gonadotropin.  |  Lapthorn, AJ., et al. 1994. Nature. 369: 455-61. PMID: 8202136
    5. Disulfide bonds 7-31 and 59-87 of the alpha-subunit play a different role in assembly of human chorionic gonadotropin and lutropin.  |  Furuhashi, M., et al. 1996. Endocrinology. 137: 4196-200. PMID: 8828477
    6. Cystine knot of the gonadotropin alpha subunit is critical for intracellular behavior but not for in vitro biological activity.  |  Sato, A., et al. 1997. J Biol Chem. 272: 18098-103. PMID: 9218442
    7. Regulation of prostaglandin F2alpha-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2alpha.  |  Väänänen, JE., et al. 1998. Endocrine. 8: 261-7. PMID: 9741831
    8. Structural and molecular studies of human chorionic gonadotropin and its receptor.  |  Lustbader, JW., et al. 1998. Recent Prog Horm Res. 53: 395-424; discussion 424-5. PMID: 9769716

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Gonadotropin Antibody (ME-105)

    sc-57186
    100 µg/ml
    $316.00