GnT-IVA Antibody (M-71): sc-100785

GnT-IVA Antibody (M-71) is a mouse monoclonal IgG1 kappa light chain antibody that detects GnT-IVA protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-GnT-IVA antibody (M-71) is available as non-conjugated format. GnT-IVA protein, also known as N-acetylglucosaminyltransferase IVA, GlcNAc-T IVa, or MGAT4A, is a type II single-pass membrane protein belonging to glycosyltransferase 54 family. GnT-IVA (M-71) antibody recognizes a protein primarily localized to Golgi apparatus membrane and expressed in various human tissues, including thymus, pancreas, prostate, small intestine, lymph nodes, spleen, and peripheral blood leukocytes. GnT-IVA protein plays a crucial role in glycosylation by catalyzing N-acetylglucosamine (GlcNAc) transfer to mannose residues of N-linked glycans, essential for tri- and multi-antennary structure formation. This process is vital for proper protein folding, stability, and function, influencing cell differentiation and oncogenesis. GnT-IVA has been implicated in choriocarcinoma development and serves as a genetic marker for pancreatic cancer, with expression often down-regulated in cancerous tissues. GnT-IVA′s ability to modulate glycan structures highlights importance in cellular communication and disease progression, making GnT-IVA (M-71) monoclonal antibody valuable for research in cancer biology and glycosylation pathways.

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GnT-IVA Antibody (M-71) References:

1. Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.  |  Takamatsu, S., et al. 1999. Cancer Res. 59: 3949-53. PMID: 10463590
2. The widespread effect of beta 1,4-galactosyltransferase on N-glycan processing.  |  Fukuta, K., et al. 2001. Arch Biochem Biophys. 392: 79-86. PMID: 11469797
3. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.  |  Ohtsubo, K., et al. 2005. Cell. 123: 1307-21. PMID: 16377570
4. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.  |  Ide, Y., et al. 2006. Biochem Biophys Res Commun. 341: 478-82. PMID: 16434023
5. A toggle for type 2 diabetes?  |  Thorens, B. 2006. N Engl J Med. 354: 1636-8. PMID: 16611957
6. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.  |  Oguri, S., et al. 2006. Glycoconj J. 23: 473-80. PMID: 17006639
7. N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.  |  Kudo, T., et al. 2007. Mol Cancer. 6: 32. PMID: 17488527
8. The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients.  |  López-Orduña, E., et al. 2007. BMC Genet. 8: 73. PMID: 17953760

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GnT-IVA Antibody (M-71) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-GnT-IVA Antibody (M-71) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GnT-IVA Antibody (M-71) Specifications

Alternate Product Name: GnT-IVA

Product Clone Name: M-71

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 436-536

Epitope Target: GnT-IVA

Epitope Species: human

Product Reactivity/Detection: GnT-IVA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for GnT-IVA Antibody (M-71): N/A