GnRHR Antibody (GRX-8): sc-69847
- GnRHR Antibody (GRX-8) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against synthetic peptide corresponding to aa's 1-31 of GnRHR of human origin
- recommended for detection of GnRHR of human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GnRHR Antibody (GRX-8). This work is in progress.
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GnRHR Antibody (GRX-8) is a mouse monoclonal IgM antibody that detects gonadotropin-releasing hormone receptor (GnRHR) in human samples through applications such as western blotting (WB) and immunofluorescence (IF). Anti-GnRHR antibody (GRX-8) recognizes a protein crucial for reproductive hormone release, serving as the primary receptor for gonadotropin-releasing hormone, which drives the pulsatile release of luteinizing hormone and follicle-stimulating hormone from the pituitary gland. GnRHR monoclonal antibody (GRX-8) targets a unique structure characterized by seven transmembrane domains that effectively transduce signals across the cell membrane, initiating a cascade of intracellular events influencing reproductive function. The absence of an intracellular C-terminal domain in GnRHR distinguishes this receptor from many other G-protein coupled receptors, potentially impacting signaling mechanisms and interactions with downstream effectors. Understanding GnRHR′s structural nuances is vital, as alterations in function can lead to reproductive disorders, making GnRHR (GRX-8) antibody an invaluable tool for researchers studying reproductive health and related conditions.
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GnRHR Antibody (GRX-8) References:
- Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus. | Castro-Fernández, C. and Conn, PM. 2002. Mol Cell Endocrinol. 191: 149-56. PMID: 12062898
- Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. | Leaños-Miranda, A., et al. 2003. J Clin Endocrinol Metab. 88: 3360-7. PMID: 12843188
- Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice. | Ishaq, M., et al. 2013. J Mol Endocrinol. 50: 411-26. PMID: 23536650
- Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. | Houck, SA., et al. 2014. Mol Cell. 54: 166-179. PMID: 24685158
- The Central Effect of β-Endorphin and Naloxone on The Biosynthesis of GnRH and GnRH Receptor (GnRHR) in The Hypothalamic-Pituitary Unit of Follicular-Phase Ewes. | Ciechanowska, M., et al. 2016. Reprod Domest Anim. 51: 555-61. PMID: 27335238
- The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs. | Bjelobaba, I., et al. 2016. Mol Cell Endocrinol. 437: 302-311. PMID: 27569529
- Anti-cancer effect of GV1001 for prostate cancer: function as a ligand of GnRHR. | Kim, JW., et al. 2019. Endocr Relat Cancer. 26: 147-162. PMID: 30400054
- A novel GNRHR gene mutation causing congenital hypogonadotrophic hypogonadism in a Brazilian kindred. | Correa-Silva, SR., et al. 2018. J Neuroendocrinol. 30: e12658. PMID: 30415482
- A novel compound variant in GNRHR causing congenital idiopathic hypogonadotropic hypogonadism in a young male Korean patient. | Lee, G., et al. 2023. Ann Pediatr Endocrinol Metab. 28: S20-S22. PMID: 35798295
- Impact of Perinatal Coexposure to Chlorpyrifos and a High-Fat Diet on Kisspeptin and GnRHR Presence and Reproductive Organs. | Lahimer, M., et al. 2023. Toxics. 11: PMID: 37755799
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GnRHR Antibody (GRX-8) | sc-69847 | 200 µg/ml | $322.00 |