GnRHR Antibody (GRX-6): sc-69846
- GnRHR Antibody (GRX-6) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against synthetic peptide corresponding to aa's 1-31 of GnRHR of human origin
- recommended for detection of GnRHR of human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GnRHR Antibody (GRX-6). This work is in progress.
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GnRHR Antibody (GRX-6) is a mouse monoclonal IgG1 antibody that detects gonadotropin-releasing hormone receptor (GnRHR) in human samples through applications such as western blotting (WB) and immunofluorescence (IF). GnRHR plays a crucial role in the regulation of reproductive hormone release, as GnRHR is the primary receptor for gonadotropin-releasing hormone, which is essential for the synthesis and secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gland. The unique structure of GnRHR, characterized by seven transmembrane domains, allows GnRHR to effectively transduce signals across the cell membrane, initiating a cascade of intracellular events that ultimately influence reproductive function. The absence of an intracellular C-terminal domain in GnRHR distinguishes GnRHR from many other G-protein coupled receptors, potentially impacting signaling mechanisms and interactions with downstream effectors. Understanding the structure and function of GnRHR is vital, as alterations in GnRHR signaling can lead to reproductive disorders, making anti-GnRHR antibody (GRX-6) an invaluable tool for researchers studying reproductive health and related conditions.
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GnRHR Antibody (GRX-6) References:
- Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment. | Pawson, AJ., et al. 2005. Endocrinology. 146: 2639-49. PMID: 15761034
- Effect of short-term and prolonged stress on the biosynthesis of gonadotropin-releasing hormone (GnRH) and GnRH receptor (GnRHR) in the hypothalamus and GnRHR in the pituitary of ewes during various physiological states. | Ciechanowska, M., et al. 2016. Anim Reprod Sci. 174: 65-72. PMID: 27629353
- GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism. | Gonçalves, CI., et al. 2017. Endocr Connect. 6: 360-366. PMID: 28611058
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. | Odle, AK., et al. 2018. Endocrinology. 159: 883-894. PMID: 29228137
- Genetics of ncHH: from a peculiar inheritance of a novel GNRHR mutation to a comprehensive review of the literature. | Cioppi, F., et al. 2019. Andrology. 7: 88-101. PMID: 30575316
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. | Odle, AK., et al. 2021. Int J Mol Sci. 22: PMID: 33805020
- Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway. | Fu, Y., et al. 2022. Int J Nanomedicine. 17: 1549-1566. PMID: 35401001
- GNRHR-related central hypogonadism with spontaneous recovery - case report. | Šmigoc Schweiger, D., et al. 2022. Ital J Pediatr. 48: 184. PMID: 36371229
- Gonadotropin-Releasing Hormone Receptor (GnRHR) and Hypogonadotropic Hypogonadism. | Fanis, P., et al. 2023. Int J Mol Sci. 24: PMID: 37958948
- Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R. | Yang, S., et al. 2024. Endocrinology. 165: PMID: 39254333
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GnRHR Antibody (GRX-6) | sc-69846 | 200 µg/ml | $322.00 |