GMPPA Antibody (Y-2D78): sc-134348

GMPPA Antibody (Y-2D78) is a mouse monoclonal IgG2a kappa light chain antibody that detects GMPPA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GMPPA antibody (Y-2D78) is available as a non-conjugated format. GMPPA, or GDP-mannose pyrophosphorylase A, is a 420 amino acid protein that plays a crucial role in the biosynthesis of nucleotide-sugars, which are essential for various cellular processes, including glycosylation and protein modification. GMPPA (Y-2D78) antibody recognizes an enzyme that catalyzes the conversion of alpha-D-mannose 1-phosphate and GTP to GDP-mannose and diphosphate, a reaction vital for proper functioning of glycoproteins and glycolipids. The gene encoding GMPPA is located on human chromosome two, which houses over 1,400 genes and comprises nearly 8% of the human genome. GMPPA is expressed as two isoforms due to alternative splicing events, which may contribute to functional diversity and regulatory mechanisms within different tissues.

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GMPPA Antibody (Y-2D78) References:

1. Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins.  |  Ning, B. and Elbein, AD. 2000. Eur J Biochem. 267: 6866-74. PMID: 11082198
2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 2001. DNA Res. 8: 85-95. PMID: 11347906
3. Complete sequencing and characterization of 21,243 full-length human cDNAs.  |  Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
4. Identification of a GDP-mannose pyrophosphorylase gene from Sulfolobus solfataricus.  |  Sacchetti, S., et al. 2004. Gene. 332: 149-57. PMID: 15145064
5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
6. GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability of Aspergillus fumigatus.  |  Jiang, H., et al. 2008. Microbiology (Reading). 154: 2730-2739. PMID: 18757806
7. Functional characterization of GDP-mannose pyrophosphorylase from Leptospira interrogans serovar Copenhageni.  |  Asención Diez, MD., et al. 2010. Arch Microbiol. 192: 103-14. PMID: 20035319