Molecular structure of GM 6001, CAS Number: 142880-36-2
GM 6001 (CAS 142880-36-2)
See product citations (55)
Alternate Names:
Galardin; Ilomastat
Application:
GM 6001 is a cell permeable MMP and fibroblast collagenase inhibitor
CAS Number:
142880-36-2
Purity:
≥97%
Molecular Weight:
388.46
Molecular Formula:
C20H28N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GM 6001, a cell-permeable hydroxamic acid isomer, has been reported to potently inhibit human skin MMP-1 (fibroblast collagenase Ki = 0.4nM) Additionally, this compound may act to act as an antagonist of TNFalpha release and processing in cells. Furthermore, GM 6001 has displayed the capacity to block several MMP (matrix metalloproteases), which are enzymes thought to be involved in angiogenesis. GM 6001, Negative Control is available as sc-295025. GM 6001 is an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MT-MMP-1 (MMP-14), MMP-26.
GM 6001 (CAS 142880-36-2) References
- Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. | Grobelny, D., et al. 1992. Biochemistry. 31: 7152-4. PMID: 1322694
- Homocysteine causes cerebrovascular leakage in mice. | Lominadze, D., et al. 2006. Am J Physiol Heart Circ Physiol. 290: H1206-13. PMID: 16258031
- Balamuthia mandrillaris exhibits metalloprotease activities. | Matin, A., et al. 2006. FEMS Immunol Med Microbiol. 47: 83-91. PMID: 16706791
- Latanoprost-induced changes in rat intraocular pressure: direct or indirect? | Husain, S., et al. 2008. J Ocul Pharmacol Ther. 24: 367-72. PMID: 18665807
- Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. | McNulty, AL., et al. 2009. Clin Orthop Relat Res. 467: 1557-67. PMID: 18975039
- Detection of in vivo matrix metalloproteinase activity using microdialysis sampling and liquid chromatography/mass spectrometry. | Wang, Y., et al. 2009. Anal Chem. 81: 9961-71. PMID: 19904964
- A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix. | Liu, T., et al. 2009. Electrophoresis. 30: 4285-91. PMID: 20013914
- Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. | Rodrigues, SF., et al. 2010. Am J Physiol Heart Circ Physiol. 299: H25-35. PMID: 20382857
- Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain. | Hoehna, Y., et al. 2012. Neurobiol Dis. 48: 339-47. PMID: 22782080
- Matrix metalloproteinase 14 in the zebrafish: an eye on retinal and retinotectal development. | Janssens, E., et al. 2013. PLoS One. 8: e52915. PMID: 23326364
- Role of MMP-9 in the breakdown of barrier integrity of the corneal endothelium in response to TNF-α. | Rajashekhar, G., et al. 2014. Exp Eye Res. 122: 77-85. PMID: 24667088
- Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition. | Altshuler, AE., et al. 2014. PLoS One. 9: e96655. PMID: 24805256
- Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer. | Huang, YH., et al. 2021. Sci Rep. 11: 12171. PMID: 34108545
- Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. | Galardy, RE., et al. 1994. Cancer Res. 54: 4715-8. PMID: 7520359
- A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality. | Solorzano, CC., et al. 1997. Shock. 7: 427-31. PMID: 9185243
Inhibitor of:
α2-Macroglobulin, α2ML1, 5430419D17Rik, ADAM18, ADAM2, ADAM20, ADAM21, ADAM24, ADAM25, ADAM26, ADAM26B, ADAM29, ADAM32, ADAM34, ADAM38, ADAM39, ADAM6A, ADAM6B, ADAMTS-19, ADAMTS-20, ADAMTS-6, ADAMTS-8, ADAMTS-9, ADAMTS-L5, AMZ1, ART1, BC048546, C1q-A, C8γ, cadherin-7, Cdhr4, CEACAM16, CEACAM3, CLAP, COL14A1, COL22A1, COL6A4, Collagen α1, CPM, CPXM2, Ddc8, Dispase I, Dlx-4, EG210155, EG384813, EG665186, EGFL11, EGFL3, EGFL8, EMID1, Enzyme, Erd2, Fibulin-7, Filamin β, FND3C2, FRAS1, FREM2, GOLGA6A-D, GOLGA6D, GOLGA6L4, GOLGA7B, GOLPH3, HAPLN3, hemicentin-2, HKIB9, Hmcn2, ICAM-5, Intra-acrosomal protein, JAM (junction adhesion molecule), KIAA0247, KLK (Kallikrein related peptidase), Laminin γ-3, LEPREL2, Lingo-2, LMLN, LOXL2, Lunapark, Ly6/uPAR (LYNX; Ly6/neurotoxin), LYPD1, Lysozyme C, Mast Cell Protease 4, Mast Cell Protease 9, Matriptase-2, MBLAC2, MCC, Meprin A, Meprin A alpha, METH-1, Microfibril associated protein (MFAP), MMP, MMP-1, MMP-10, MMP-12, MMP-1a, MMP-1b, MMP-2, MMP-20, MMP-26, MMP-7, MMP-8, MMP-9, MT-MMP-1, murinoglobulin 1, MXRA5, MXRA7, NAALADL2, Ninjurin-2, OTTMUSG00000008561, OTTMUSG00000016293, Papilin, PCDH20_Pcdh20, PCDHA4, PDF, PF4V1, pilD, Podocan, POEM, PRG-3, Psg16, SSc5D, Syndecan-3, TATI, TEM8, TIMP-4, TIN-Ag, TLL1, TLL2, TMED4, TMED7, TMPRSS11A, TMPRSS11F, TMPRSS5, TNFa-IP 8, Vmn2r70, Vrho, VWA8, WECHE, YIPF1, and YIPF3.Activator of:
ADAM21, ADAM23, ADAM24, ADAM25, ADAM28, ADAM8, ADAMTS-10, ADAMTS-12, ADAMTS-13, ADAMTS-14, ADAMTS-15, ADAMTS-16, ADAMTS-17, ADAMTS-2, ADAMTS-3, ADAMTS-4, BPI, CMG1, COL8A1, LMLN, LTBP-4, MMP-19, MMP-1b, MT-MMP-1, MT-MMP-4, MT-MMP-6, neurocan, and Testican-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GM 6001, 1 mg | sc-203979 | 1 mg | $75.00 | |||
GM 6001, 5 mg | sc-203979A | 5 mg | $265.00 |