Molecular structure of GM 1489, CAS Number: 170905-75-6
GM 1489 (CAS 170905-75-6)
Alternate Names:
N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide
Application:
GM 1489 is a potent broad-range inhibitor of matrix metalloproteinases
CAS Number:
170905-75-6
Purity:
>95%
Molecular Weight:
463.57
Molecular Formula:
C27H33N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GM 1489 is a potent broad-range inhibitor of MMP (matrix metalloproteinases). It inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1 Ki = 500 nM for MMP-2 Ki = 20 muM for MMP-3 Ki = 100 nM for MMP-8 and Ki = 100 nM for MMP-9). Additionally, it reduces 5-aza-2′-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. GM 1489 also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
GM 1489 (CAS 170905-75-6) References
- Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex. | Mei, JM., et al. 2002. Carcinogenesis. 23: 2119-22. PMID: 12507936
- Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. | Sato, N., et al. 2003. J Natl Cancer Inst. 95: 327-30. PMID: 12591989
- Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells. | Kocer, SS., et al. 2005. Infect Immun. 73: 7548-57. PMID: 16239558
- Identification and properties of proteases from an Acanthamoeba isolate capable of producing granulomatous encephalitis. | Sissons, J., et al. 2006. BMC Microbiol. 6: 42. PMID: 16672059
- Balamuthia mandrillaris exhibits metalloprotease activities. | Matin, A., et al. 2006. FEMS Immunol Med Microbiol. 47: 83-91. PMID: 16706791
- Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways. | Bogatkevich, GS., et al. 2007. Arthritis Rheum. 56: 3468-77. PMID: 17907155
- Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives. | Chiang, CC., et al. 2008. Chem Pharm Bull (Tokyo). 56: 369-73. PMID: 18310951
- Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. | Beshir, AB., et al. 2010. Cancer Lett. 299: 137-49. PMID: 20855151
- Experimental etch-and-rinse adhesive systems containing MMP-inhibitors: Physicochemical characterization and resin-dentin bonding stability. | da Silva, EM., et al. 2015. J Dent. 43: 1491-7. PMID: 26456899
- Bond stability of conventional adhesive system with MMP inhibitors to superficial and deep dentin. | Simmer, FS., et al. 2019. J Mech Behav Biomed Mater. 100: 103402. PMID: 31493688
- Resin-dentin bond stability of etch-and-rinse adhesive systems with different concentrations of MMP inhibitor GM1489. | Miranda, MEDSNG., et al. 2020. J Appl Oral Sci. 28: e20190499. PMID: 32348441
- Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies. | Yaghmoor, RB., et al. 2022. Jpn Dent Sci Rev. 58: 298-315. PMID: 36247748
- Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia. | Holleran, WM., et al. 1997. Arch Dermatol Res. 289: 138-44. PMID: 9128761
Inhibitor of:
Enzyme, and MMP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GM 1489, 1 mg | sc-203978 | 1 mg | $110.00 | |||
GM 1489, 5 mg | sc-203978A | 5 mg | $497.00 |