Date published: 2025-10-16

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Glycylglycine, Free Base (CAS 556-50-3)

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Alternate Names:
2-[(2-aminoacetyl)amino]acetic acid
Application:
Glycylglycine, Free Base is a dipeptide used as a buffering reagent
CAS Number:
556-50-3
Purity:
≥99%
Molecular Weight:
132.12
Molecular Formula:
C4H8N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Glycylglycine (Gly-Gly) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Also useful as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.


Glycylglycine, Free Base (CAS 556-50-3) References

  1. Mutation analysis of the histidine residues in the glycylglycine endopeptidase ALE-1.  |  Fujiwara, T., et al. 2005. J Bacteriol. 187: 480-7. PMID: 15629919
  2. Glycylglycine decreases the size of conspicuous facial pores: Single-blinded half areas of face-applied study.  |  Iida, T., et al. 2009. J Dermatol. 36: 120-3. PMID: 19284462
  3. Photoemission and photoabsorption spectroscopy of glycyl-glycine in the gas phase.  |  Feyer, V., et al. 2009. J Phys Chem A. 113: 10726-33. PMID: 19757775
  4. Studies of enthalpy-entropy compensation, partial entropies, and Kirkwood-Buff integrals for aqueous solutions of glycine, L-leucine, and glycylglycine at 298.15 K.  |  Kurhe, DN., et al. 2009. J Phys Chem B. 113: 16612-21. PMID: 19924870
  5. Rat kidney brush border enzyme activity following subchronic oral lead exposure.  |  Teichert-Kuliszewska, K. and Nicholls, DM. 1985. Toxicol Appl Pharmacol. 77: 211-8. PMID: 2858132
  6. Metal-ligated amino acids and peptides as substrates for proteases.  |  Bagger, S. 1987. Int J Pept Protein Res. 30: 99-101. PMID: 3667081
  7. Energetics of glycylglycine transport in Escherichia coli.  |  Cowell, JL. 1974. J Bacteriol. 120: 139-46. PMID: 4278690
  8. Differential modulation of rat heart mitochondrial membrane-associated enzymes by dietary lipid.  |  McMurchie, EJ., et al. 1983. Biochim Biophys Acta. 760: 13-24. PMID: 6311280
  9. Isoelectric focusing of immunoglobulins: improved methodology.  |  Nicolotti, RA., et al. 1980. J Immunol Methods. 33: 101-15. PMID: 6768804
  10. Impairment of jejunal absorption rate of carnosine by glycylglycine in man in vivo.  |  Cook, GC. 1976. Gut. 17: 252-7. PMID: 773786

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Glycylglycine, Free Base, 25 g

sc-202633
25 g
$28.00

Glycylglycine, Free Base, 100 g

sc-202633A
100 g
$70.00

We ordered Glycylglycine, free base, lot:I1015. For our purpose the impurity of glycine in glycylglycine shall not exceed 0,1%. This impurity is not mentioned in the COA. The purity of glycylglicine is 99.9%, shall the glycine impurity be <0,1%?

Asked by: Anja Spaans
Thank you for your question. The purity was determined by titration. However, based on the age of the lot we would recommend that you retest the product before use. Please contact our Technical Service Department for additional support. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-12-04
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Rated 5 out of 5 by from Various publications cite Glycylglycine (FreeVarious publications cite Glycylglycine (Free Base) for its use in peptide transport and absorption assays. It is also a practical buffer above a pH of 8.0. -SCBT Publication Review
Date published: 2015-05-22
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Glycylglycine, Free Base is rated 5.0 out of 5 by 1.
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