Date published: 2025-12-6

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Glycolic acid (CAS 79-14-1)

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Alternate Names:
Hydroxyacetic acid
Application:
Glycolic acid is a constituent of sugar cane juice
CAS Number:
79-14-1
Molecular Weight:
76.05
Molecular Formula:
C2H4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Glycolic acid, an alpha-hydroxy acid (AHA), has gained prominence in scientific research due to its diverse applications in various fields such as chemistry, materials science, and dermatology. Its mechanism of action primarily involves its ability to penetrate the skin and act as a chemical exfoliant by dissolving the bonds between dead skin cells, promoting their shedding and facilitating skin renewal. In research, glycolic acid is extensively utilized in the synthesis of polymers, particularly polyglycolic acid (PGA), which is a biodegradable polymer widely employed in tissue engineering and drug delivery systems. Glycolic acid′s reactivity with a wide range of compounds makes it valuable in chemical synthesis, particularly in esterification and amidation reactions to produce esters and amides, respectively. Additionally, glycolic acid serves as a crucial component in the formulation of skincare products and chemical peels used in dermatological research to improve skin texture, reduce hyperpigmentation, and treat acne and photoaging. Furthermore, its ability to chelate metal ions makes it useful in environmental research for wastewater treatment and heavy metal removal processes. Overall, glycolic acid′s multifaceted properties and versatile applications make it a valuable tool in various scientific endeavors, contributing to advancements in research across different disciplines.


Glycolic acid (CAS 79-14-1) References

  1. Inhibitory effect of glycolic acid on ultraviolet-induced skin tumorigenesis in SKH-1 hairless mice and its mechanism of action.  |  Hong, JT., et al. 2001. Mol Carcinog. 31: 152-60. PMID: 11479924
  2. Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver.  |  Booth, ED., et al. 2004. Xenobiotica. 34: 31-48. PMID: 14742135
  3. Histopathological and ultrastructural effects of glycolic acid on rat skin.  |  Inan, S., et al. 2006. Acta Histochem. 108: 37-47. PMID: 16574202
  4. Photocarcinogenesis study of glycolic acid and salicylic acid (CAS Nos. 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study).  |  ,. 2007. Natl Toxicol Program Tech Rep Ser. 1-242. PMID: 21921960
  5. Acylation of exenatide by glycolic acid and its anti-diabetic activities in db/db mice.  |  Liang, R., et al. 2014. Pharm Res. 31: 1958-66. PMID: 24549820
  6. Disposition of glycolic acid into rat and rabbit embryos in vitro.  |  Ellis-Hutchings, RG., et al. 2014. Reprod Toxicol. 46: 46-55. PMID: 24598581
  7. Photoprotective Potential of Glycolic Acid by Reducing NLRC4 and AIM2 Inflammasome Complex Proteins in UVB Radiation-Induced Normal Human Epidermal Keratinocytes and Mice.  |  Hung, SJ., et al. 2017. DNA Cell Biol. 36: 177-187. PMID: 28112987
  8. Acute Toxicity in the Rat Lung Induced by Intratracheal Instillation of Glycolic Acid.  |  Lim, SK., et al. 2022. In Vivo. 36: 1710-1717. PMID: 35738595
  9. Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition.  |  Ujlaki, G., et al. 2023. Molecules. 28: PMID: 37570868
  10. Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit.  |  Moore, NP., et al. 2024. Toxicol Sci. 198: 31-39. PMID: 38175793

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Glycolic acid, 25 g

sc-396662
25 g
$40.00

Glycolic acid, 100 g

sc-396662A
100 g
$114.00