Molecular structure of Glycogen Phosphorylase Inhibitor, CAS Number: 648926-15-2
Glycogen Phosphorylase Inhibitor (CAS 648926-15-2)
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Alternate Names:
1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
Application:
Glycogen Phosphorylase Inhibitor is a cell permeable urea compound and potent inhibitor of glycogen phosphorylase
CAS Number:
648926-15-2
Purity:
≥98%
Molecular Weight:
412.8
Molecular Formula:
C17H15ClF2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glycogen phosphorylase inhibitor is chemical compound that effectively inhibit the activity of the enzyme glycogen phosphorylase, for glycogen metabolism. As glycogen serves as a vital energy source, targeting glycogen phosphorylase presents potential for addressing metabolic disorders. Extensive research has explored the use of glycogen phosphorylase by demonstrating their ability to lower blood glucose levels and improve glucose tolerance in animal models. By inhibiting glycogen phosphorylase, these compounds reduce the release of glucose into the bloodstream and enhance glucose uptake by cells, effectively lowering blood glucose levels.
Glycogen Phosphorylase Inhibitor (CAS 648926-15-2) References
- The effects of isofagomine, a potent glycogen phosphorylase inhibitor, on glycogen metabolism in cultured mouse cortical astrocytes. | Waagepetersen, HS., et al. 2000. Neurochem Int. 36: 435-40. PMID: 10733011
- Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. | Tracey, WR., et al. 2004. Am J Physiol Heart Circ Physiol. 286: H1177-84. PMID: 14615278
- Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment. | Lee, WN., et al. 2004. Br J Cancer. 91: 2094-100. PMID: 15599384
- Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. | Klabunde, T., et al. 2005. J Med Chem. 48: 6178-93. PMID: 16190745
- Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide). | Suh, SW., et al. 2007. J Pharmacol Exp Ther. 321: 45-50. PMID: 17251391
- A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover. | Dienel, GA., et al. 2007. J Neurochem. 102: 466-78. PMID: 17442042
- Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor. | Bertus, P., et al. 2008. Bioorg Med Chem Lett. 18: 4774-8. PMID: 18701279
- Computation as a tool for glycogen phosphorylase inhibitor design. | Hayes, JM. and Leonidas, DD. 2010. Mini Rev Med Chem. 10: 1156-74. PMID: 20716053
- Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation. | Arrizabalaga, O., et al. 2012. J Biol Chem. 287: 11878-90. PMID: 22337875
- Insulin sensitivity is modified by a glycogen phosphorylase inhibitor: glucopyranosylidene-spiro-thiohydantoin in streptozotocin-induced diabetic rats. | Docsa, T., et al. 2015. Curr Top Med Chem. 15: 2390-4. PMID: 26095241
- FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma. | Li, Z., et al. 2023. bioRxiv.. PMID: 37090652
- Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. | Martin, WH., et al. 1998. Proc Natl Acad Sci U S A. 95: 1776-81. PMID: 9465093
Inhibitor of:
Enzyme, and PYGB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glycogen Phosphorylase Inhibitor, 1 mg | sc-203975 | 1 mg | $182.00 | |||
Glycogen Phosphorylase Inhibitor, 5 mg | sc-203975A | 5 mg | $714.00 |