Glycochenodeoxycholic acid, sodium salt CAS: 16564-43-5
MF: C26H42NNaO5
MW: 471.61

Glycochenodeoxycholic acid, sodium salt (CAS 16564-43-5)

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Alternate Names: Glycochenodeoxycholic acid, sodium salt is also known as GCDCA.
Application: Glycochenodeoxycholic acid, sodium salt is a bile acid shown to induce apoptosis in isolated hepatocytes.
CAS Number: 16564-43-5
Purity: ≥97%
Molecular Weight: 471.61
Molecular Formula: C26H42NNaO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Glycochenodeoxycholic acid, sodium salt is a bile acid that functions to solubilise fats for digestive absorbtion. By acting as a biosurfactant, Glycochenodeoxycholic acid, sodium salt can solubilize lipids for absorption and is itself absorbed. Glycochenodeoxycholic acid, sodium salt has been shown to inhibit calcium phosphate preciptiation by preventing the formation of amorphous calcium phosphate to calcium hydroxyapatite. Glycochenodeoxycholic acid, sodium salt has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity.


References

1. Barnes, S. et al. 1979. J. Lipid Res. 20(8): 952-959. PMID: 533830
2. Penagini, R. et al. 1989. Gut. 30(5): 609-617. PMID: 2731753
3. Qiu, S.M. et al. 1991. J. Clin. Invest. 88(4): 1265-1271. PMID: 1655828
4. Gonzalez, B. et al. 2000. Mol. Cell. Biochem. 207(1-2): 19-27. PMID: 10888222
5. Iwata, M. et al. 2003. Hepatol. Res. 25(3): 329-342. PMID: 12697255
6. Utanohara, S. et al. 2005. Toxicology. 214(1-2): 77-86. PMID: 16023280

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO, and methanol.
Storage :
Store at 4° C
Melting Point :
196-198° C
Refractive Index :
n20D ~1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23696298
MDL Number :
MFCD00036743
Beilstein Registry :
3847290

Download SDS (MSDS)

Certificate of Analysis

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Glycochenodeoxycholic acid, sodium salt (CAS 16564-43-5)  Product Citations

See how others have used Glycochenodeoxycholic acid, sodium salt (CAS 16564-43-5). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24448653  Jia, X. et al. 2014. Digestive diseases and sciences. 59: 1490-501.

PMID: # 23544269  Suzuki, Y. et al. 2013. Nagoya journal of medical science. 75: 57-71.

Citations 1 to 2 of 2 total
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