Date published: 2026-4-5

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Glycerol-d8 (CAS 7325-17-9)

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Alternate Names:
Deuterated glycerol; 1,2,3-Propanetriol-d8; Glycerin-d8; Glycerol-d8
Application:
Glycerol-d8 is a useful deuterium labeled glycerol useful in research
CAS Number:
7325-17-9
Purity:
98%
Molecular Weight:
100.14
Molecular Formula:
C3D8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Glycerol-d8, a deuterated variant of glycerol, has found extensive usage in various scientific research applications. Distinguished by the replacement of all hydrogen atoms with deuterium atoms, this unique form of glycerol allows for the observation of deuterium′s impact on the structure and reactivity of glycerol through laboratory experiments. In scientific research, glycerol-d8 has been extensively employed to investigate the structure, reactivity, and metabolism of glycerol itself. Furthermore, it has been instrumental in examining the effects of deuterium atoms on the structure and reactivity of diverse molecules, including proteins, nucleic acids, enzymes, and other biomolecules. These studies have facilitated a deeper understanding of the interplay between deuterium atoms and hydrogen atoms, elucidating consequential changes in the structure and reactivity of these molecules. Although the exact mechanism of action of glycerol-d8 remains partially elusive, it is hypothesized that the deuterium atoms within the glycerol molecule interact with hydrogen atoms in other molecules. This interaction leads to notable alterations in the structure and reactivity of the involved molecules. For instance, the deuterium atoms within glycerol may engage with hydrogen atoms in proteins, nucleic acids, and enzymes, thereby inducing modifications in their respective structures and reactivities.


Glycerol-d8 (CAS 7325-17-9) References

  1. Determination of outer-sphere dipolar time correlation functions from high-field NMR measurements. Example of a Gd(3+) complex in a viscous solvent.  |  Fries, PH., et al. 2010. J Chem Phys. 132: 044502. PMID: 20113044
  2. Solid-state dynamic nuclear polarization at 263 GHz: spectrometer design and experimental results.  |  Rosay, M., et al. 2010. Phys Chem Chem Phys. 12: 5850-60. PMID: 20449524
  3. Effect of crowding on the conformation of interwound DNA strands from neutron scattering measurements and Monte Carlo simulations.  |  Zhu, X., et al. 2010. Phys Rev E Stat Nonlin Soft Matter Phys. 81: 061905. PMID: 20866438
  4. Effect of freezing conditions on distances and their distributions derived from Double Electron Electron Resonance (DEER): a study of doubly-spin-labeled T4 lysozyme.  |  Georgieva, ER., et al. 2012. J Magn Reson. 216: 69-77. PMID: 22341208
  5. Excess wing in glass-forming glycerol and LiCl-glycerol mixtures detected by neutron scattering.  |  Gupta, S., et al. 2015. Eur Phys J E Soft Matter. 38: 1. PMID: 25612850
  6. Highly Viscous Binary Solvents: DMSO-d6/Glycerol and DMSO-d6/Glycerol-d8 for Polar and Apolar Mixture Analysis by NMR.  |  Lameiras, P. and Nuzillard, JM. 2016. Anal Chem. 88: 4508-15. PMID: 27008506
  7. Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance.  |  Carrington, B., et al. 2017. Biophys J. 113: 371-380. PMID: 28746848
  8. Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP.  |  Yokoyama, T., et al. 2017. Acta Crystallogr F Struct Biol Commun. 73: 555-559. PMID: 28994403
  9. Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties.  |  Doktorova, M., et al. 2017. Biophys J. 113: 2004-2015. PMID: 29117524
  10. Molecular Basis of Water Activity in Glycerol-Water Mixtures.  |  Nakagawa, H. and Oyama, T. 2019. Front Chem. 7: 731. PMID: 31737605
  11. Dynamics of Glyceline and Interactions of Constituents: A Multitechnique NMR Study.  |  Fraenza, CC., et al. 2022. J Phys Chem B. 126: 890-905. PMID: 35076242
  12. Nuclear Overhauser spectroscopy in hyperpolarized water - chemical vs. magnetic exchange.  |  Epasto, LM., et al. 2022. Chem Commun (Camb). 58: 11661-11664. PMID: 36169286
  13. Slow methyl axes motions in perdeuterated villin headpiece subdomain probed by cross-correlated NMR relaxation measurements.  |  Vugmeyster, L., et al. 2023. Magnetochemistry. 9: PMID: 36776538
  14. Relaxation effects in a system of a spin-1/2 nucleus coupled to a quadrupolar spin subjected to RF irradiation: evaluation of broadband decoupling schemes.  |  Smith, SA. and Murali, N. 1999. J Magn Reson. 136: 27-36. PMID: 9887286
  15. Solvent and temperature dependence of spin echo dephasing for chromium(V) and vanadyl complexes in glassy solution.  |  Eaton, GR. and Eaton, SS. 1999. J Magn Reson. 136: 63-8. PMID: 9887290

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Glycerol-d8, 1 g

sc-300767
1 g
$208.00

Glycerol-d8, 5 g

sc-300767A
5 g
$785.00