GLYAT Antibody (D-12): sc-518264
- GLYAT Antibody (D-12) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 150-177 of GLYAT of human origin
- recommended for detection of GLYAT of human origin by WB, IP, IF and ELISA
- Anti-GLYAT Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
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GLYAT Antibody (D-12) is an IgG3 kappa mouse monoclonal GLYAT antibody (also designated GLYAT antibody) that detects GLYAT of human origin by WB, IP, IF and ELISA. GLYAT Antibody (D-12) is available as the non-conjugated anti-GLYAT antibody form, as well as multiple conjugated forms of anti-GLYAT antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. GLYAT (glycine-N-acyltransferase), also known as GAT, CAT, HRP-1(CLP), Acyl-CoA:glycine N-acyltransferase (AAc) or ACGNAT, is a 296 amino acid mitochondrial acyltransferase that conjugates glycine to acyl-CoA substrates. Existing as two alternatively spliced isoforms, GLYAT may participate in detoxification of endogenous and xenobiotic acyl-CoA and is expressed in human liver at peak levels from 18 months to 40 years. Children under 7 months express only five to forty percent of liver GLYAT specific activity, thereby functioning with a lower ability to detoxify their system of certain drugs and xenobiotics. A member of the glycine N-acyltransferase family, GLYAT is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GLYAT Antibody (D-12) References:
- Glycine N-acylase: purification and properties. | SCHACHTER, D. and TAGGART, JV. 1954. J Biol Chem. 208: 263-75. PMID: 13174534
- Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver. | Mawal, YR. and Qureshi, IA. 1994. Biochem Biophys Res Commun. 205: 1373-9. PMID: 7802672
- An immunodetection method for the quantitation of human acyl CoA:glycine N-acyltransferase in biological samples. | Mawal, YR. and Qureshi, IA. 1994. Biochem Mol Biol Int. 34: 595-601. PMID: 7833837
- Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. | Merkler, DJ., et al. 1996. Arch Biochem Biophys. 330: 430-4. PMID: 8660675
- Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. | Webster, LT., et al. 1976. J Biol Chem. 251: 3352-8. PMID: 931988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GLYAT Antibody (D-12) | sc-518264 | 200 µg/ml | $322.00 | |||
GLYAT Antibody (D-12): m-IgG3 BP-HRP Bundle | sc-551789 | 200 µg Ab; 40 µg BP | $361.00 | |||
GLYAT Antibody (D-12) AC | sc-518264 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GLYAT Antibody (D-12) HRP | sc-518264 HRP | 200 µg/ml | $322.00 | |||
GLYAT Antibody (D-12) FITC | sc-518264 FITC | 200 µg/ml | $336.00 | |||
GLYAT Antibody (D-12) PE | sc-518264 PE | 200 µg/ml | $349.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 488 | sc-518264 AF488 | 200 µg/ml | $364.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 546 | sc-518264 AF546 | 200 µg/ml | $364.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 594 | sc-518264 AF594 | 200 µg/ml | $364.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 647 | sc-518264 AF647 | 200 µg/ml | $364.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 680 | sc-518264 AF680 | 200 µg/ml | $364.00 | |||
GLYAT Antibody (D-12) Alexa Fluor® 790 | sc-518264 AF790 | 200 µg/ml | $364.00 |